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Kelch Lab
Biochemistry and Molecular Biotechnology
Page Menu
New Kelch Lab
Home
Research
DNA Polymerase Clamp Loaders
Virus Assembly
Action of Enzymes on Sliding Clamps
Structural and Mechanistic Studies of Alternative Clamp Loaders
Publications
The Lab
The PI
Lab Members
Lab Alumni
Lab Culture
Lab News
Collaborators
Memes
Contact
Our most recent publications:
Total:
displaying 10 out of
15
results
Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication
Friday, March 15, 2024
Author(s):
Jacob T Landeck,Joshua Pajak,Emily K Norman,Emma L Sedivy,Brian A Kelch
Source:
The Journal of biological chemistry
Differences in clamp loader mechanism between bacteria and eukaryotes
Monday, December 11, 2023
Author(s):
Jacob T Landeck,Joshua Pajak,Emily K Norman,Emma L Sedivy,Brian A Kelch
Source:
bioRxiv : the preprint server for biology
A thermosensitive PCNA allele underlies an ataxia-telangiectasia-like disorder
Wednesday, March 29, 2023
Author(s):
Joseph Magrino,Veridiana Munford,Davi Jardim Martins,Thais K Homma,Brendan Page,Christl Gaubitz,Bruna L Freire,Antonio M Lerario,Juliana Brandstetter Vilar,Antonio Amorin,Emília K E Leão,Fernando Kok,...
Source:
The Journal of biological chemistry
Conformational dynamics control assembly of an extremely long bacteriophage tail tube
Wednesday, February 15, 2023
Author(s):
Emily Agnello,Joshua Pajak,Xingchen Liu,Brian A Kelch
Source:
The Journal of biological chemistry
Unexpected new insights into DNA clamp loaders: Eukaryotic clamp loaders contain a second DNA site for recessed 5' ends that facilitates repair and signals DNA damage: Eukaryotic clamp loaders contain a second DNA site for recessed 5' ends that facilitates repair and signals DNA damage
Sunday, September 18, 2022
Author(s):
Huilin Li,Mike O'Donnell,Brian Kelch
Source:
BioEssays : news and reviews in molecular, cellular and developmental biology
CaMKII binds both substrates and activators at the active site
Wednesday, July 13, 2022
Author(s):
Can Özden,Roman Sloutsky,Tomohiro Mitsugi,Nicholas Santos,Emily Agnello,Christl Gaubitz,Joshua Foster,Emily Lapinskas,Edward A Esposito,Takeo Saneyoshi,Brian A Kelch,Scott C Garman,Yasunori Hayashi,Ma...
Source:
Cell reports
A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA
Wednesday, June 22, 2022
Author(s):
Xingchen Liu,Christl Gaubitz,Joshua Pajak,Brian A Kelch
Source:
eLife
Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader
Friday, February 18, 2022
Author(s):
Christl Gaubitz,Xingchen Liu,Joshua Pajak,Nicholas P Stone,Janelle A Hayes,Gabriel Demo,Brian A Kelch
Source:
eLife
Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor
Saturday, May 29, 2021
Author(s):
Joshua Pajak,Erik Dill,Emilio Reyes-Aldrete,Mark A White,Brian A Kelch,Paul J Jardine,Gaurav Arya,Marc C Morais
Source:
Nucleic acids research
Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation
Friday, April 23, 2021
Author(s):
Joshua Pajak,Rockney Atz,Brendan J Hilbert,Marc C Morais,Brian A Kelch,Paul J Jardine,Gaurav Arya
Source:
Proceedings of the National Academy of Sciences of the United States of America
Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1
Tuesday, February 23, 2021
Author(s):
Jennifer A Calvo,Briana Fritchman,Desiree Hernandez,Nicole S Persky,Cory M Johannessen,Federica Piccioni,Brian A Kelch,Sharon B Cantor
Source:
Molecular cancer research : MCR
Exploring the Evolutionary History of Kinetic Stability in the α-Lytic Protease Family
Tuesday, January 12, 2021
Author(s):
Charlotte F Nixon,Shion A Lim,Zachary R Sailer,Ivan N Zheludev,Christine L Gee,Brian A Kelch,Michael J Harms,Susan Marqusee
Source:
Biochemistry
Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch
Thursday, September 10, 2020
Author(s):
Christl Gaubitz,Xingchen Liu,Joseph Magrino,Nicholas P Stone,Jacob Landeck,Mark Hedglin,Brian A Kelch
Source:
Proceedings of the National Academy of Sciences of the United States of America
A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry
Wednesday, February 05, 2020
Author(s):
Janelle A Hayes,Brendan J Hilbert,Christl Gaubitz,Nicholas P Stone,Brian A Kelch
Source:
The Journal of biological chemistry
Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure
Friday, October 04, 2019
Author(s):
Nicholas P Stone,Gabriel Demo,Emily Agnello,Brian A Kelch
Source:
Nature communications
In the News
Latest INSERT LAB NAME HERE news as reported by the UMass Chan Communications Office
Faculty shine at Educational Recognition Awards ceremony, Last Lecture
April 26, 2024
New Kelch Lab
Home
Research
DNA Polymerase Clamp Loaders
Virus Assembly
Action of Enzymes on Sliding Clamps
Structural and Mechanistic Studies of Alternative Clamp Loaders
Publications
The Lab
The PI
Lab Members
Lab Alumni
Lab Culture
Lab News
Collaborators
Memes
Contact
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