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Department of Medicine

Research is core to the mission of the Department of Medicine. The Department has an exceptional foundation in basic research and is nationally recognized for its success in building interdisciplinary teams capable of supporting high-quality clinical research. Department investigators across several divisions have created outstanding research programs spanning basic, translational and clinical research. Investigators are supported by department-based initiatives, such as the Clinical Research Core, which expand investigators’ capabilities, enhance collaboration, and support rapid discovery and translation. Additionally,  interdepartmental and interdisciplinary programs such as the Program in Innate Immunity and Program in Digital Medicine also contribute to the ingenuity and vitality of the Department's investigators and research labs. These programs offer investigators unique resources and opportunities for collaboration within their divisions and the department, as well as interdepartmentally at UMass Chan Medical School.

The Department of Medicine is committed to providing a diverse, equitable, and inclusive environment for our faculty, postdocs, students, and staff. We oppose discrimination in all forms and strive to educate ourselves about systemic issues by actively engaging in an ongoing dialogue and learning from all members of the program as well as the broader community. We believe that by doing so, we not only strive to provide an environment that is welcoming to all but that also enriches our personal and professional perspectives and approaches to our research and clinical care.

Please access and learn more about our open positions that are posted to the right of the page.

Dr. Hardy Kornfeld - Division of Pulmonary, Allergy and Critical Care

The Kornfeld Lab’s research focuses on host defense against bacterial and viral respiratory pathogens with an emphasis on tuberculosis, specifically:

  • Immunometabolism of tuberculosis and tuberculosis-diabetes interaction
  • Host-directed tuberculosis therapy
  • Post-tuberculosis lung disease

Learn more about Dr. Kornfeld’s work

Dr. Kate Fitzgerald - Division of Infectious Diseases and Immunology Program in Innate Immunity

The Fitzgerald Lab’s research focuses on understanding molecular mechanisms controlling inflammatory response, specifically:

  • Sensing and signaling in innate immunity (TLRs, Inflammasomes, cGAS/STING)
  • Autoinflammatory diseases (e.g., SAVI - STING associated Vasculopathy with onset in Infancy)
  • Therapeutic targeting of Inflammasomes and cGAS/STING Signaling

 Learn more about Dr. Fitzgerald’s work

Dr. Megan Orzalli - Division of Infectious Diseases and Immunology

The Orzalli Lab’s research focuses on virus-host interactions and host immune response, specifically:

  • Antiviral Immunity and Inflammation at Barrier Surfaces
  • 3D Skin Organoids

 Learn more about Dr. Orzalli’s work

Dr. Neil Aronin - Division of Endocrinology and Metabolism

The Aronin Lab’s research focuses on developing approaches for Huntington’s Disease therapeutics. Specifically, they are interested in:

  • RNA interference-based reduction of the mutant mRNA by microRNA delivered in adeno-associated virus
  • Advanced di-valent siRNA delivered to brain to reduce mutant huntingtin mRNA
  • Gene editing to eliminate the mutant huntingtin gene or correct the mutation

Learn more about Dr. Aronin’s work

Dr. David McManus - Division of Cardiovascular Medicine

The McManus Lab’s research focuses on the development and testing of novel point-of-care technologies across the heart, lung, blood and sleep spectrum, specifically,

  • Enhancing the early detection of undiagnosed cardiovascular conditions using digital devices
  • Improving outcomes among older adults with heart disease leveraging electronic data resources
  • Understanding use of wearables for improving cardiovascular health

 Learn more about Dr. McManus’ work

Dr. Shaoguang Li - Division of Hematology/Oncology

The Li Lab’s research focuses on molecular basis of leukemogenesis and myeloproliferative neoplasms, specifically:

  • Understanding the biology of leukemia stem cells (LSCs)
  • Identification of molecular targets specific for LSCs
  • Elucidation of signaling pathways critical for the development of myeloproliferative neoplasms (MPNs), with a focus on polycythemia vera (PV) induced by JAK2V617F
  • Understanding the biology of PV-initiating cells
  • Characterization of the self-renewal mechanisms of normal hematopoietic stem cells

 Learn more about Dr. Li’s work