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Biochemistry and Molecular Biotechnology Department

Our mission is to illuminate the molecular mechanisms that govern basic biological processes, with an emphasis on integrative strategies to reveal fundamental mechanistic insights and develop new therapeutic paradigms empowered by a collaborative, diverse & inclusive community.

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BMB Blog Posts

May 10, 2024

Dr. Brian Kelch Receives the Education Service Award, 2024

Dr. Brian Kelch received the Education Service Award in 2024! Learn more about his dedication to education in this blog post.

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May 6, 2024

Dr. Celia Schiffer elected to the National Academy of Sciences

Breaking news! Dr. Celia Schiffer, the Chair and the Arthur F. and Helen P. Koskinas Professor of Biochemistry & Molecular Biotechnology, and the Director of the Institute for Drug Resistance, was elected to the National Academy of Sciences!

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Latest News

Latest BMB news as reported by the UMass Chan Communications Office

Celia A. Schiffer elected to National Academy of Sciences

May 03, 2024
Mary Munson, Craig Peterson named American Association for the Advancement of Science fellows

April 18, 2024

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Recent Publications

Total: 15 results

Chitosan Phytate Nanoparticles: A Synergistic Strategy for Effective Dental Caries Prevention

Wednesday, May 15, 2024

Author(s): Weibo Jiang,Jing Peng,Nan Jiang,Wenyi Zhang,Shuang Liu,Jianmin Li,Dengyi Duan,Yiming Li,Cheng Peng,Yongfa Yan,Yang Zhao,Gang Han

Source: ACS nano
Triggered Release of Ampicillin from Metallic Implant Coatings for Combating Periprosthetic Infections

Wednesday, May 01, 2024

Author(s): Feiyang Chen,Jordan D Skelly,Shing-Yun Chang,Jie Song

Source: ACS applied materials & interfaces
Ebola Virus Glycoprotein Strongly Binds to Membranes in the Absence of Receptor Engagement

Monday, April 29, 2024

Author(s): Alisa Vaknin,Alon Grossman,Natasha D Durham,Inbal Lupovitz,Shahar Goren,Gonen Golani,Yael Roichman,James B Munro,Raya Sorkin

Source: ACS infectious diseases
Expanding the Potential of Neoantigen Vaccines: Harnessing Bacille Calmette-Guérin Cell-Wall-Based Nanoscale Adjuvants for Enhanced Cancer Immunotherapy

Monday, April 29, 2024

Author(s): Kangkang Liu,Jing Peng,Yunfei Guo,Yiming Li,Xiang Qi,Dengyi Duan,Taipeng Li,Jianmin Li,Yuanjie Niu,Gang Han,Yang Zhao

Source: ACS nano
A single cell atlas of the mouse seminal vesicle

Monday, April 22, 2024

Author(s): Fengyun Sun,Kathleen Desevin,Yu Fu,Shanmathi Parameswaran,Jemma Mayall,Vera Rinaldi,Nils Krietenstein,Artur Manukyan,Qiangzong Yin,Carolina Galan,Chih-Hsiang Yang,Anastasia V Shindyapina,Vadim N Glady...

Source: bioRxiv : the preprint server for biology
Muscle-Specific Pyruvate Kinase Isoforms, Pkm1 and Pkm2, Regulate Mammalian SWI/SNF Proteins and Histone 3 Phosphorylation During Myoblast Differentiation

Monday, April 22, 2024

Author(s): Monserrat Olea-Flores,Tapan Sharma,Odette Verdejo-Torres,Imaru DiBartolomeo,Paul R Thompson,Teresita Padilla-Benavides,Anthony N Imbalzano

Source: bioRxiv : the preprint server for biology
Leveraging shape screening and molecular dynamics simulations to optimize PARP1-Specific chemo/radio-potentiators for antitumor drug design

Saturday, April 20, 2024

Author(s): Hifza Khizer,Arooma Maryam,Adnan Ansari,Muhammad Sajjad Ahmad,Rana Rehan Khalid

Source: Archives of biochemistry and biophysics
Nuclear bodies: a gene expression collection for our time

Sunday, April 14, 2024

Author(s): Thoru Pederson

Source: Nucleus (Austin, Tex.)
Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo

Saturday, April 13, 2024

Author(s): Samantha L Sarli,Hassan H Fakih,Karen Kelly,Gitali Devi,Julia M Rembetsy-Brown,Holly R McEachern,Chantal M Ferguson,Dimas Echeverria,Jonathan Lee,Jacquelyn Sousa,Hanadi F Sleiman,Anastasia Khvorova,Jo...

Source: Nucleic acids research
Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer

Thursday, April 04, 2024

Author(s): Alok K Mishra,Tianyi Ye,Shahid Banday,Ritesh P Thakare,Chinh Tran-To Su,Ngoc N H Pham,Amjad Ali,Ankur Kulshreshtha,Shreya Roy Chowdhury,Tessa M Simone,Kai Hu,Lihua Julie Zhu,Birgit Eisenhaber,Sara K D...

Source: Cell reports
Triplet-triplet annihilation photon upconversion-mediated photochemical reactions

Friday, March 22, 2024

Author(s): Ling Huang,Gang Han

Source: Nature reviews. Chemistry
Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia

Thursday, March 21, 2024

Author(s): Salome Funes,Jonathan Jung,Del Hayden Gadd,Michelle Mosqueda,Jianjun Zhong,None Shankaracharya,Matthew Unger,Karly Stallworth,Debra Cameron,Melissa S Rotunno,Pepper Dawes,Megan Fowler-Magaw,Pamela J K...

Source: Nature communications
Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication

Friday, March 15, 2024

Author(s): Jacob T Landeck,Joshua Pajak,Emily K Norman,Emma L Sedivy,Brian A Kelch

Source: The Journal of biological chemistry
Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance

Tuesday, March 12, 2024

Author(s): Julia M Flynn,Sarah N Zvornicanin,Tenzin Tsepal,Ala M Shaqra,Nese Kurt Yilmaz,Weiping Jia,Stephanie Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon

Source: ACS infectious diseases
Silencing Parkinson's risk allele Rit2 sex-specifically compromises motor function and dopamine neuron viability

Friday, February 23, 2024

Author(s): Patrick J Kearney,Yuanxi Zhang,Marianna Liang,Yanglan Tan,Elizabeth Kahuno,Tucker L Conklin,Rita R Fagan,Rebecca G Pavchinskiy,Scott A Shaffer,Zhenyu Yue,Haley E Melikian

Source: NPJ Parkinson's disease

A full list of department publications can be found here.

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