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Biochemistry and Molecular Biotechnology Department

Our mission is to illuminate the molecular mechanisms that govern basic biological processes, with an emphasis on integrative strategies to reveal fundamental mechanistic insights and develop new therapeutic paradigms empowered by a collaborative, diverse & inclusive community.

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BMB Blog Posts

Jul 31, 2024

Celebrating RNA Day with Dr. Thoru Pederson

Join us (the BMB) in celebrating RNA Day by learning more about the innovative bioengineering by the Pederson Lab.

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May 10, 2024

Dr. Brian Kelch Receives the Education Service Award, 2024

Dr. Brian Kelch received the Education Service Award in 2024! Learn more about his dedication to education in this blog post.

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Check out more of our blogs here!

Latest News

Latest BMB news as reported by the UMass Chan Communications Office

UMass Chan community invited to ponder meaning of ‘advancing together’ at art exhibit

September 25, 2024
UMass Memorial Health gift, with matching funds from UMass Foundation, to fund five new endowed chairs at UMass Chan

September 19, 2024
Convocation 2024: UMass Chan racing toward ambitious future

September 13, 2024
Morningside Graduate School of Biomedical Sciences celebrates largest class at qualifying exam ceremony

September 12, 2024
UMass Chan kicks off 2024 academic year with weeklong Convocation celebration

August 30, 2024
UMass Chan neuroscientist receives $4.1 million Transformative Research Award to study Down syndrome

July 16, 2024
UMass Chan BRIDGE Fund commits $2M in six faculty projects

July 03, 2024
Morningside Graduate School of Biomedical Sciences celebrates milestones of IMSD, PREP students

June 18, 2024
Advancing gender equity, importance of mentoring highlighted at Women’s Faculty Awards

May 24, 2024
Twenty rising faculty members graduate from Junior Faculty Development Program

May 17, 2024
Celia A. Schiffer elected to National Academy of Sciences

May 03, 2024
Mary Munson, Craig Peterson named American Association for the Advancement of Science fellows

April 18, 2024
Zhiping Weng named inaugural chair of the Department of Genomics & Computational Biology

November 03, 2023
Celebrating collaboration, UMass Chan launches ‘Advancing Together’ brand

September 06, 2023
Kirschstein award to fund PhD candidate’s research on HTLV-1

August 16, 2023
Summer undergraduate research students highlight collaboration, diversity at UMass Chan

August 10, 2023

Check out more news here!

Recent Publications

Total: 15 results

piRNA Defense Against Endogenous Retroviruses

Wednesday, November 27, 2024

Author(s): Milky Abajorga,Leonid Yurkovetskiy,Jeremy Luban

Source: Viruses
Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition

Tuesday, November 26, 2024

Author(s): Minwoo Nam,Wenxin Xia,Abdul Hannan Mir,Alexandra Jerrett,Jessica B Spinelli,Tony T Huang,Richard Possemato

Source: Nature metabolism
The centennial of E.B. Wilson's The Cell in Development and Heredity

Thursday, November 21, 2024

Author(s): Jane Maienschein,Martin Chalfie,Thoru Pederson

Source: Molecular biology of the cell
Efficient convergent synthesis of 1,3-diazepinone nucleosides by ring-closing metathesis and direct glycosylation

Thursday, November 21, 2024

Author(s): Adam K Hedger,Jonathan Findell,Dinesh S Barak,Celia A Schiffer,Jonathan K Watts,Akbar Ali

Source: RSC advances
Dominant negative mutations in yeast Hsp90 indicate triage decision mechanism targeting client proteins for degradation

Wednesday, November 20, 2024

Author(s): Julia M Flynn,Margot E Joyce,Daniel N A Bolon

Source: Molecular biology of the cell
In remembrance: Joseph Gall

Wednesday, November 20, 2024

Author(s): Thoru Pederson

Source: Nucleus (Austin, Tex.)
A quantitative intracellular peptide binding assay reveals recognition determinants and context dependence of short linear motifs

Monday, November 18, 2024

Author(s): Mythili S Subbanna,Matthew J Winters,Mihkel Örd,Norman E Davey,Peter M Pryciak

Source: bioRxiv : the preprint server for biology
An integrated view of the structure and function of the human 4D nucleome

Friday, November 01, 2024

Author(s): 4D Nucleome Consortium,Job Dekker,Betul Akgol Oksuz,Yang Zhang,Ye Wang,Miriam K Minsk,Shuzhen Kuang,Liyan Yang,Johan H Gibcus,Nils Krietenstein,Oliver J Rando,Jie Xu,Derek H Janssens,Steven Henikoff,A...

Source: bioRxiv : the preprint server for biology
Quantifying and mitigating motor phenotypes induced by antisense oligonucleotides in the central nervous system

Saturday, October 26, 2024

Author(s): Michael P Moazami,Julia M Rembetsy-Brown,Samantha L Sarli,Holly R McEachern,Feng Wang,Masahiro Ohara,Atish Wagh,Karen Kelly,Pranathi Meda Krishnamurthy,Alexandra Weiss,Miklos Marosfoi,Robert M King,Mo...

Source: Molecular therapy : the journal of the American Society of Gene Therapy
AFM41a: A Novel PAD2 Inhibitor for Sepsis Treatment-Efficacy and Mechanism

Monday, October 21, 2024

Author(s): Tao Dong,Leonard Barasa,Xin Yu,Wenlu Ouyang,Liujiazi Shao,Chao Quan,Su He Wang,Jifeng Zhang,Morgan Salmon,Allan Tsung,Hasan B Alam,Jianjie Ma,Paul R Thompson,Yongqing Li

Source: International journal of biological sciences
A Hydrophobic Core Stabilizes the Residual Structure in the RRM2 Intermediate State of the ALS-linked Protein TDP-43

Saturday, October 19, 2024

Author(s): Brian C Mackness,Brittany R Morgan,Laura M Deveau,Sagar V Kathuria,Jill A Zitzewitz,Francesca Massi

Source: Journal of molecular biology
Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution

Friday, October 04, 2024

Author(s): Shuvankar Dey,Purba Pahari,Srija Mukherjee,James B Munro,Dibyendu Kumar Das

Source: Structure (London, England : 1993)
Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance

Saturday, September 28, 2024

Author(s): Vincent N Azzolino,Ala M Shaqra,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer

Source: Viruses
FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques

Thursday, September 26, 2024

Author(s): Joanna Zikos,Gabriela M Webb,Helen L Wu,Jason S Reed,Jennifer Watanabe,Jodie L Usachenko,Ala M Shaqra,Celia A Schiffer,Koen K A Van Rompay,Jonah B Sacha,Diogo M Magnani

Source: mAbs
Increasing intracellular dNTP levels improves prime editing efficiency

Wednesday, September 25, 2024

Author(s): Pengpeng Liu,Karthikeyan Ponnienselvan,Thomas Nyalile,Sarah Oikemus,Anya T Joynt,Sukanya Iyer,Karen Kelly,Dongsheng Guo,Pyae P Kyawe,Emma Vanderleeden,Sambra D Redick,Lei Huang,Zexiang Chen,Jeong Min ...

Source: Nature biotechnology

A full list of department publications can be found here.

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December 2024

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