Our long term research goal is to understand the molecular mechanisms driving cellular responses to their environment.

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Signaling responses to yeast mating pheromones involve the dynamic assemblyof amembrane-localized complex, nucleated by membrane recruitment of the MAP kinasecascade scaffold protein, Ste5.This recruitment event requires the concerted action ofprotein-protein and protein-membrane interactions.The functional benefits of thiscooperative arrangement are one area of continuing exploration.oNext, at the start of a new cell cycle, Ste5 recruitment is inhibited by CDKphosphorylation. Our recent findings reveal unexpected factors underlying this CDKcontrol, including previously unknown recognition motifs that guide specific forms ofcyclin-CDK to their substrates. These recent discoveries propel new projects on howCDK phosphorylation networks are defined by cyclin-substrate docking interactions.

Research Areas

Commonly-Used Techniques

A list of commonly-used techniques in your lab to orient prospective trainees.