Research by scientists at UMass Medical School that shows how argonaute proteins rewrite the rules to make oligonucleotides behave like RNA-binding proteins is the topic of a paper selected by the Oligonucleotide Therapeutics Society as its 2015-16 Paper of the Year. The paper, “Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides,” appeared in the July 2015 issue of Cell. The award honors the most impactful paper in the field of oligonucleotide therapeutics.
Researchers include William E. Salomon, PhD, postdoctoral fellow in the RNA Therapeutics Institute; Samson M. Jolly, fourth-year medical student; Melissa J. Moore, PhD, Howard Hughes Medical Institute Investigator, the Eleanor Eustis Farrington Chair of Cancer Research and professor of biochemistry & molecular pharmacology; Phillip D. Zamore, PhD, Howard Hughes Medical Institute Investigator, the Gretchen Stone Cook Professor of Biomedical Sciences and chair and professor of the RNA Therapeutics Institute; and Victor Serebrov, PhD, instructor in the RNA Therapeutics Institute.
The award will be presented at the Oligonucleotide Therapeutics Society Annual Meeting in Montreal in September.