Neurons are nerve cells in the brain that can be excited or inhibited by neighboring cells. This level of excitation and inhibition in the brain is critical to nervous system function and defects are thought to underlie a number of neuropsychiatric disorders including schizophrenia and autism. The current project will investigate how resident immune cells of the brain called microglia regulate levels of excitation and inhibition and explore how this regulation is disrupted in mouse models of autism spectrum disorders.
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