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Publications (selected)

Hypercholesterolemia Accelerates the Aging Phenotypes of Hematopoietic Stem Cells by a Tet1-Dependent Pathway.
Tie G, Yan J, Khair L, Tutto A, Messina LM.
Sci Rep. 2020 Feb 27;10(1):3567. doi: 10.1038/s41598-020-60403-w. PMID: 32107419 

Type 2 diabetes impairs the ability of skeletal muscle pericytes to augment postischemic neovascularization in db/db mice.
Hayes KL, Messina LM, Schwartz LM, Yan J, Burnside AS, Witkowski S.
Am J Physiol Cell Physiol. 2018 May 1;314(5):C534-C544. doi: 10.1152/ajpcell.00158.2017. Epub 2018 Jan 10. PMID: 29351404

Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.
Yan J, Tie G, Wang S, Tutto A, DeMarco N, Khair L, Fazzio TG, Messina LM.
Nat Commun. 2018 Jan 2;9(1):33. doi: 10.1038/s41467-017-02425-z. PMID: 29295997

Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells.
Tie G, Yan J, Khair L, Messina JA, Deng A, Kang J, Fazzio T, Messina LM.
Cancer Res. 2017 May 1;77(9):2351-2362. doi: 10.1158/0008-5472.CAN-16-1916. Epub 2017 Mar 1. PMID: 28249902

Toward a Biological Therapy to Improve Stroke Outcomes After Thrombolytic Therapy.
Messina LM.
Circulation. 2015 Dec 8;132(23):2201-2. doi: 10.1161/CIRCULATIONAHA.115.019446. Epub 2015 Oct 27. PMID: 26508732

Inhibition of p38 Mitogen-Activated Protein Kinase Enhances the Apoptosis Induced by Oxidized Low-Density Lipoprotein in Endothelial Progenitor Cells.
Tie G, Yan J, Messina JA, Raffai RL, Messina LM.
J Vasc Res. 2015;52(6):361-71. doi: 10.1159/000443889. Epub 2016 Apr 1.PMID: 27031525

Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells.
Tie G, Messina KE, Yan J, Messina JA, Messina LM.
J Am Heart Assoc. 2014 Jan 27;3(1):e000241. doi: 10.1161/JAHA.113.000241. PMID: 24470519

Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics.
Shimasaki Y, Pan N, Messina LM, Li C, Chen K, Liu L, Cooper MP, Vita JA, Keaney JF Jr. Circ Res. 2013 Sep 13;113(7):891-901. doi: 10.1161/CIRCRESAHA.113.301319. Epub 2013 Jul 2. PMID: 23819990

Mesenchymal stem cells as a treatment for peripheral arterial disease: current status and potential impact of type II diabetes on their therapeutic efficacy.
Yan J, Tie G, Xu TY, Cecchini K, Messina LM.
Stem Cell Rev. 2013 Jun;9(3):360-72. doi: 10.1007/s12015-013-9433-8. Review. PMID: 23475434

Type 2 diabetes restricts multipotency of mesenchymal stem cells and impairs their capacity to augment postischemic neovascularization in db/db mice.
Yan J, Tie G, Wang S, Messina KE, DiDato S, Guo S, Messina LM.
J Am Heart Assoc. 2012 Dec;1(6):e002238. doi: 10.1161/JAHA.112.002238. Epub 2012 Dec 19. PMID: 23316315

Tetrahydrobiopterin, L-arginine and vitamin C act synergistically to decrease oxidant stress and increase nitric oxide that increases blood flow recovery after hindlimb ischemia in the rat.
Yan J, Tie G, Messina LM.  Mol Med. 2012 Oct 24;18:1221-30. doi:  10.2119/molmed.2011.00103.revised. PMID: 23212846

ApoE suppresses atherosclerosis by reducing lipid accumulation in circulating monocytes and the expression of inflammatory molecules on monocytes and vascular endothelium.
Gaudreault N, Kumar N, Posada JM, Stephens KB, Reyes de Mochel NS, Eberlé D, Olivas VR, Kim RY, Harms MJ, Johnson S, Messina LM, Rapp JH, Raffai RL.
Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):264-72. doi: 10.1161/ATVBAHA.111.238964. Epub 2011 Nov 3. PMID: 22053073

Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results.
Flotte TR, Trapnell BC, Humphries M, Carey B, Calcedo R, Rouhani F, Campbell-Thompson M, Yachnis AT, Sandhaus RA, McElvaney NG, Mueller C, Messina LM, Wilson JM, Brantly M, Knop DR, Ye GJ, Chulay JD.
Hum Gene Ther. 2011 Oct;22(10):1239-47. doi: 10.1089/hum.2011.053. Epub 2011 Aug 24. PMID: 21609134

Oral tetrahydrobiopterin improves the beneficial effect of adenoviral-mediated eNOS gene transfer after induction of hindlimb ischemia.
Yan J, Tie G, Hoffman A, Yang Y, Nowicki PT, Messina LM
Mol Ther. 2010 Aug;18(8):1482-9. doi: 10.1038/mt.2010.109. Epub 2010 Jun 15. PMID: 20551918

Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway.
Tie G, Yan J, Yang Y, Park BD, Messina JA, Raffai RL, Nowicki PT, Messina LM.  
J Vasc Res. 2010;47(6):519-30. doi: 10.1159/000313879. Epub 2010 Apr 30.PMID: 20431300

Endothelial nitric oxide synthase affects both early and late collateral arterial adaptation and blood flow recovery after induction of hind limb ischemia in mice.
Park B, Hoffman A, Yang Y, Yan J, Tie G, Bagshahi H, Nowicki PT, Messina LM.
J Vasc Surg. 2010 Jan;51(1):165-73. doi: 10.1016/j.jvs.2009.08.045. Epub 2009 Oct 30. PMID: 19879098

Recovery from hind limb ischemia is less effective in type 2 than in type 1 diabetic mice: roles of endothelial nitric oxide synthase and endothelial progenitor cells.
Yan J, Tie G, Park B, Yan Y, Nowicki PT, Messina LM.
J Vasc Surg. 2009 Dec;50(6):1412-22. doi: 10.1016/j.jvs.2009.08.007. Epub 2009 Oct 17. PMID: 19837544

Cellular and molecular mechanism regulating blood flow recovery in acute versus gradual femoral artery occlusion are distinct in the mouse.
Yang Y, Tang G, Yan J, Park B, Hoffman A, Tie G, Wang R, Messina LM.
J Vasc Surg. 2008 Dec;48(6):1546-58. doi: 10.1016/j.jvs.2008.07.063. PMID: 19118738

Elucidating the genetic basis of peripheral arterial disease: identification of a quantitative trait locus that determines the phenotypic response to experimental hindlimb ischemia.
Messina LM.
Circulation. 2008 Mar 4;117(9):1127-9. doi: 10.1161/CIRCULATIONAHA.107.752055. No abstract available. PMID: 18316497

Optimization of adenovirus-mediated endothelial nitric oxide synthase delivery in rat hindlimb ischemia.
Yan J, Tang GL, Wang R, Messina LM.
Gene Ther. 2005 Nov;12(22):1640-50. PMID: 16107865

Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice.
Carlson TR, Yan Y, Wu X, Lam MT, Tang GL, Beverly LJ, Messina LM, Capobianco AJ, Werb Z, Wang R.
Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9884-9. Epub 2005 Jun 30. Erratum in: Proc Natl Acad Sci U S A. 2006 May 9;103(19):7530. PMID: 15994223