We study how human cells sense and respond to mechanical stress.
Cellular responses to mechanical strain are critical for regeneration, and tissue homeostasis, and are frequently mis-regulated in cancer. Understanding how these processes work is important for devising approaches for organ regeneration and cancer treatment.
We use a combination of molecular and cell biology, genome editing, and computational modeling to determine at a molecular level how cells sense and respond to mechanical strain.
We are a collaborative team of dedicated researchers dedicated to discovering fundamental principles in cell biology.
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The ability of the LIMD1 and TRIP6 LIM domains to bind strained f-actin is critical for their tension dependent localization to adherens junctions and association with the Hippo pathway kinase LATS1
Ray, S., DeSilva, C., Dasgupta, I., Mana-Capelli, S., Cruz-Calderon, N, McCollum, D.
Cryoskeleton (Hoboken) Sep 2024. Epub March 2024. PMCID: PMC11366040.
TRIP6 inhibits Hippo signaling in response to tension at adherens junctions
Dutta, S., ManaCapelli, S., Paramasivam, M, Dasgupta, I., Cirka, H., Billiar, K., McCollum, D.
EMBO Rep 2018. PMCID: PMC5797958
Angiomotins link F-actin architecture to Hippo pathway signaling
Mana-Capelli, S,Paramasiva, M, Dutta, S., McCollum, D.
