The Lab

The LabRegulation of cell fate determination by the Hippo signaling pathway

The main interest of my lab is understanding how the Hippo signaling pathway controls cell fate decisions in response to a diverse array of stimuli, in particular mechanical forces. The Hippo pathway is a protein kinase-mediated network that regulates cell proliferation, contact inhibition, apoptosis, stem cell maintenance, differentiation, and tissue regeneration. Misregulation of this pathway has deleterious effects on cells and organisms and can lead to cancer. Hippo signaling controls the nuclear localization of the transcriptional co-activator YAP in response to various stimuli that affect the mechanical environment of the cell such as cell crowding, substrate stiffness, tension, and cell detachment. The ability to sense these types of changes to the mechanical environment is crucial for regulation of stem cell niches, wound healing, contact inhibition of growth, and tumor suppression. My lab uses cell and molecular biology, genetics, and biochemical approaches to determine how cells sense changes in the mechanical environment and regulate cell fate through control of Hippo signaling.

Meet the Lab

 

Publications

Kobertz PublicationsAngiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling.

Author(s): Mana-Capelli S, McCollum D.

 

Follow our research, stay in touch – join the lab! 


Contact Us

Office:
Lazare Research Building 823
Campus Map (pdf)

Phone:
508-856-8767 (office)

Email:
Dannel.McCollum@umassmed.edu

Mailing Address:
University of Massachusetts Medical School
Attn: Dr. Dannel McCollum/BMP department
364 Plantation St LRB823
Worcester, MA 01605

Join Us

We are always interested in applications from qualified candidates at postdoctoral and research associate levels.

Read more here

Undergraduates interested in pursuing a PhD at UMass Medical School should apply directly to the Graduate School of Biomedical Sciences Program.