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We are interested in understanding how changes in metabolic pathways support cancer cells and their survival within the tumor environment, and in exploiting these changes for therapeutic purposes. We have found that cancer cells are dependent on metabolic pathways which involve the formation of toxic metabolites. We aim to understand the role of these pathways, and to target these pathways to poison cancer cells with their own metabolites. Furthermore, as widespread changes in cellular metabolism accompany various physiological and pathological changes in cellular state, we are also interested in the potential roles of toxic metabolites in contexts outside of cancer.

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