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Total: displaying 10 out of 15 results

TDP-43 dysfunction leads to impaired proteostasis and predisposes mice to worse neurological outcomes after brain injury

Monday, November 24, 2025

Author(s): Melissa S Rotunno,Megan Fowler-Magaw,Jianjun Zhong,Kennedy O'Hara,Elenore A Wiggin,Debra Cameron,Karly Stallworth,James Bouley,Holly McEachern,Mina N Anadolu,Jeffrey A Nickerson,Andrew R Tapper,Susann...

Source: bioRxiv : the preprint server for biology
A conserved triple arginine motif in OMA-1 is required for RNA-binding activity and embryo viability

Wednesday, August 27, 2025

Author(s): Asli Ertekin,Sharon T Noronha,Christable Darko,Francesca Massi,Sean P Ryder

Source: RNA (New York, N.Y.)
A conserved triple arginine motif in OMA-1 is required for RNA-binding activity and embryo viability

Wednesday, June 04, 2025

Author(s): Asli Ertekin,Sharon T Noronha,Christable Darko,Francesca Massi,Sean P Ryder

Source: bioRxiv : the preprint server for biology
A Hydrophobic Core Stabilizes the Residual Structure in the RRM2 Intermediate State of the ALS-linked Protein TDP-43

Saturday, October 19, 2024

Author(s): Brian C Mackness,Brittany R Morgan,Laura M Deveau,Sagar V Kathuria,Jill A Zitzewitz,Francesca Massi

Source: Journal of molecular biology
Structure and Dynamics of the CCCH-Type Tandem Zinc Finger Domain of POS-1 and Implications for RNA Binding Specificity

Wednesday, September 25, 2024

Author(s): Asli Ertekin,Brittany R Morgan,Sean P Ryder,Francesca Massi

Source: Biochemistry
A hydrophobic core stabilizes the residual structure in the RRM2 intermediate state of the ALS-linked protein TDP-43

Tuesday, June 25, 2024

Author(s): Brian C Mackness,Brittany R Morgan,Laura M Deveau,Sagar V Kathuria,Jill A Zitzewitz,Francesca Massi

Source: bioRxiv : the preprint server for biology
Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia

Thursday, March 21, 2024

Author(s): Salome Funes,Jonathan Jung,Del Hayden Gadd,Michelle Mosqueda,Jianjun Zhong,None Shankaracharya,Matthew Unger,Karly Stallworth,Debra Cameron,Melissa S Rotunno,Pepper Dawes,Megan Fowler-Magaw,Pamela J K...

Source: Nature communications
A nematode model to evaluate microdeletion phenotype expression

Monday, November 13, 2023

Author(s): Katianna R Antkowiak,Peren Coskun,Sharon T Noronha,Davide Tavella,Francesca Massi,Sean P Ryder

Source: G3 (Bethesda, Md.)
Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia

Monday, July 03, 2023

Author(s): Salome Funes,Del Hayden Gadd,Michelle Mosqueda,Jianjun Zhong,Jonathan Jung,None Shankaracharya,Matthew Unger,Debra Cameron,Pepper Dawes,Pamela J Keagle,Justin A McDonough,Sivakumar Boopathy,Miguel Sen...

Source: bioRxiv : the preprint server for biology
The Role of Substrate Mediated Allostery in the Catalytic Competency of the Bacterial Oligosaccharyltransferase PglB

Monday, October 04, 2021

Author(s): Brittany R Morgan,Francesca Massi

Source: Frontiers in molecular biosciences
ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-induced actin polymerization

Wednesday, June 02, 2021

Author(s): Eric J Schmidt,Salome Funes,Jeanne E McKeon,Brittany R Morgan,Sivakumar Boopathy,Lauren C O'Connor,Osman Bilsel,Francesca Massi,Antoine Jégou,Daryl A Bosco

Source: Proceedings of the National Academy of Sciences of the United States of America
Analysis of Emerging Variants in Structured Regions of the SARS-CoV-2 Genome

Friday, May 21, 2021

Author(s): Sean P Ryder,Brittany R Morgan,Peren Coskun,Katianna Antkowiak,Francesca Massi

Source: Evolutionary bioinformatics online
Analysis of Rapidly Emerging Variants in Structured Regions of the SARS-CoV-2 Genome

Thursday, June 25, 2020

Author(s): Sean P Ryder,Brittany R Morgan,Francesca Massi

Source: bioRxiv : the preprint server for biology
A Disorder-to-Order Transition Mediates RNA Binding of the Caenorhabditis elegans Protein MEX-5

Thursday, April 16, 2020

Author(s): Davide Tavella,Asli Ertekin,Hila Schaal,Sean P Ryder,Francesca Massi

Source: Biophysical journal
Networks of electrostatic and hydrophobic interactions modulate the complex folding free energy surface of a designed βα protein

Sunday, March 17, 2019

Author(s): Sujit Basak,R Paul Nobrega,Davide Tavella,Laura M Deveau,Nobuyasu Koga,Rie Tatsumi-Koga,David Baker,Francesca Massi,C Robert Matthews

Source: Proceedings of the National Academy of Sciences of the United States of America

In the News

Latest BMB news as reported by the UMass Chan Communications Office

Top story: UMass Chan celebrates naming of Paul J. DiMare Center

December 15, 2025
PhD candidate Emily Sholi receives grant to study pathogens’ impact on ribosomes

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Chancellor Collins’ final Convocation address encourages optimism, determination

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Inspired by faculty mentor, MD/PhD candidate pursuing dermatology

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UMass Chan celebrates naming of Paul J. DiMare Center

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Kristen Matteson and Mary Munson selected for Executive Leadership in Academic Medicine Program for Women

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Educational Recognition Awards, Last Lecture celebrate UMass Chan’s collaborative environment

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Origen Biotechnology funds research at UMass Chan to advance gene therapy technology

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UMass Chan faculty present translational research at BRIDGE Fund Innovation Showcase

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New research examines mechanisms of protein complex at basic cell biological level

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PhD student among first to join UMass Chan program focused on quantitative skills

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UMass Chan community invited to ponder meaning of ‘advancing together’ at art exhibit

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UMass Memorial Health gift, with matching funds from UMass Foundation, to fund five new endowed chairs at UMass Chan

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Convocation 2024: UMass Chan racing toward ambitious future

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Morningside Graduate School of Biomedical Sciences celebrates largest class at qualifying exam ceremony

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