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Kurt Yilmaz Lab
Biochemistry and Molecular Biotechnology
Research
Research
Overview
Structural Basis of Resistance in Viral Drug Targets
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About Nese Kurt Yilmaz
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Kurt Yilmaz Lab
Home
Research
Overview
Structural Basis of Resistance in Viral Drug Targets
Manuscript Highlights
Publications
Lab Members
About Nese Kurt Yilmaz
Lab Members
Collaborations
Contact Us
BMB Home
Kurt Yilmaz Lab
Home
Research
Overview
Structural Basis of Resistance in Viral Drug Targets
Manuscript Highlights
Publications
Lab Members
About Nese Kurt Yilmaz
Lab Members
Collaborations
Contact Us
BMB Home
Publications
Total:
displaying 50 out of
93
results
HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues
Saturday, May 27, 2023
Author(s):
Gordon J Lockbaum,Linah N Rusere,Mina Henes,Klajdi Kosovrasti,Desaboini Nageswara Rao,Ean Spielvogel,Sook-Kyung Lee,Ellen A Nalivaika,Ronald Swanstrom,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
Source:
European journal of medicinal chemistry
Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses
Thursday, March 30, 2023
Author(s):
Sarah N Zvornicanin,Ala M Shaqra,Qiuyu J Huang,Elizabeth Ornelas,Mallika Moghe,Mark Knapp,Stephanie Moquin,Dustin Dovala,Celia A Schiffer,Nese Kurt Yilmaz
Source:
Viruses
Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance
Wednesday, March 15, 2023
Author(s):
Ean Spielvogel,Sook-Kyung Lee,Shuntai Zhou,Gordon J Lockbaum,Mina Henes,Amy Sondgeroth,Klajdi Kosovrasti,Ellen A Nalivaika,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer,Ronald Swanstrom
Source:
eLife
Allosteric quinoxaline-based inhibitors of the flavivirus NS2B/NS3 protease
Tuesday, November 29, 2022
Author(s):
Jacqueto Zephyr,Desaboini Nageswara Rao,Colby Johnson,Ala M Shaqra,Ellen A Nalivaika,Aria Jordan,Nese Kurt Yilmaz,Akbar Ali,Celia A Schiffer
Source:
Bioorganic chemistry
Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants
Thursday, September 29, 2022
Author(s):
Qi Li,Fiachra Humphries,Roxie C Girardin,Aaron Wallace,Monir Ejemel,Alla Amcheslavsky,Conor T McMahon,Zachary A Schiller,Zepei Ma,John Cruz,Alan P Dupuis,Anne F Payne,Arooma Maryam,Nese Kurt Yilmaz,Ka...
Source:
Frontiers in immunology
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance
Tuesday, June 21, 2022
Author(s):
Ala M Shaqra,Sarah N Zvornicanin,Qiu Yu J Huang,Gordon J Lockbaum,Mark Knapp,Laura Tandeske,David T Bakan,Julia Flynn,Daniel N A Bolon,Stephanie Moquin,Dustin Dovala,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Nature communications
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
Monday, June 20, 2022
Author(s):
Julia M Flynn,Neha Samant,Gily Schneider-Nachum,David T Barkan,Nese Kurt Yilmaz,Celia A Schiffer,Stephanie A Moquin,Dustin Dovala,Daniel N A Bolon
Source:
eLife
Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance
Sunday, February 20, 2022
Author(s):
Jacqueto Zephyr,Desaboini Nageswara Rao,Sang V Vo,Mina Henes,Klajdi Kosovrasti,Ashley N Matthew,Adam K Hedger,Jennifer Timm,Elise T Chan,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of molecular biology
Viral proteases: Structure, mechanism and inhibition
Saturday, December 04, 2021
Author(s):
Jacqueto Zephyr,Nese Kurt Yilmaz,Celia A Schiffer
Source:
The Enzymes
Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode
Friday, September 10, 2021
Author(s):
Gordon J Lockbaum,Mina Henes,Jeong Min Lee,Jennifer Timm,Ellen A Nalivaika,Paul R Thompson,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Biochemistry
Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants
Wednesday, August 18, 2021
Author(s):
Desaboini Nageswara Rao,Jacqueto Zephyr,Mina Henes,Elise T Chan,Ashley N Matthew,Adam K Hedger,Hasahn L Conway,Mohsan Saeed,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt Yilmaz,Celia A Schi...
Source:
Journal of medicinal chemistry
Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s
Friday, June 25, 2021
Author(s):
Shurong Hou,Jeong Min Lee,Wazo Myint,Hiroshi Matsuo,Nese Kurt Yilmaz,Celia A Schiffer
Source:
The Journal of biological chemistry
Deciphering Antifungal Drug Resistance in Pneumocystis jirovecii DHFR with Molecular Dynamics and Machine Learning
Thursday, June 17, 2021
Author(s):
Florian Leidner,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of chemical information and modeling
Deciphering Complex Mechanisms of Resistance and Loss of Potency through Coupled Molecular Dynamics and Machine Learning
Tuesday, March 30, 2021
Author(s):
Florian Leidner,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of chemical theory and computation
Introduction: Drug Resistance
Wednesday, March 24, 2021
Author(s):
Nese Kurt Yilmaz,Celia A Schiffer
Source:
Chemical reviews
Inhibiting HTLV-1 Protease: A Viable Antiviral Target
Tuesday, February 23, 2021
Author(s):
Gordon J Lockbaum,Mina Henes,Nathaniel Talledge,Linah N Rusere,Klajdi Kosovrasti,Ellen A Nalivaika,Mohan Somasundaran,Akbar Ali,Louis M Mansky,Nese Kurt Yilmaz,Celia A Schiffer
Source:
ACS chemical biology
Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188
Thursday, January 28, 2021
Author(s):
Gordon J Lockbaum,Archie C Reyes,Jeong Min Lee,Ronak Tilvawala,Ellen A Nalivaika,Akbar Ali,Nese Kurt Yilmaz,Paul R Thompson,Celia A Schiffer
Source:
Viruses
Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond
Thursday, January 07, 2021
Author(s):
Ashley N Matthew,Florian Leidner,Gordon J Lockbaum,Mina Henes,Jacqueto Zephyr,Shurong Hou,Desaboini Nageswara Rao,Jennifer Timm,Linah N Rusere,Debra A Ragland,Janet L Paulsen,Kristina Prachanronarong,...
Source:
Chemical reviews
Crystal Structure of a Soluble APOBEC3G Variant Suggests ssDNA to Bind in a Channel that Extends between the Two Domains
Sunday, October 25, 2020
Author(s):
Atanu Maiti,Wazo Myint,Krista A Delviks-Frankenberry,Shurong Hou,Tapan Kanai,Vanivilasini Balachandran,Christina Sierra Rodriguez,Rashmi Tripathi,Nese Kurt Yilmaz,Vinay K Pathak,Celia A Schiffer,Hiros...
Source:
Journal of molecular biology
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction
Sunday, August 23, 2020
Author(s):
Monir Ejemel,Qi Li,Shurong Hou,Zachary A Schiller,Julia A Tree,Aaron Wallace,Alla Amcheslavsky,Nese Kurt Yilmaz,Karen R Buttigieg,Michael J Elmore,Kerry Godwin,Naomi Coombes,Jacqueline R Toomey,Ryan S...
Source:
Nature communications
Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes
Wednesday, July 29, 2020
Author(s):
Erica P Cai,Yuki Ishikawa,Wei Zhang,Nayara C Leite,Jian Li,Shurong Hou,Badr Kiaf,Jennifer Hollister-Lock,Nese Kurt Yilmaz,Celia A Schiffer,Douglas A Melton,Stephan Kissler,Peng Yi
Source:
Nature metabolism
Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere
Friday, July 17, 2020
Author(s):
Linah N Rusere,Gordon J Lockbaum,Mina Henes,Sook-Kyung Lee,Ean Spielvogel,Desaboini Nageswara Rao,Klajdi Kosovrasti,Ellen A Nalivaika,Ronald Swanstrom,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
Source:
Journal of medicinal chemistry
IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity
Tuesday, June 09, 2020
Author(s):
Monir Ejemel,Qi Li,Shurong Hou,Zachary A Schiller,Aaron L Wallace,Alla Amcheslavsky,Nese Kurt Yilmaz,Jacqueline R Toomey,Ryan Schneider,Brianna J Close,Da-Yuan Chen,Hasahn L Conway,Saeed Mohsan,Lisa A...
Source:
bioRxiv : the preprint server for biology
Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors
Friday, April 03, 2020
Author(s):
Ashley N Matthew,Jacqueto Zephyr,Desaboini Nageswara Rao,Mina Henes,Wasih Kamran,Klajdi Kosovrasti,Adam K Hedger,Gordon J Lockbaum,Jennifer Timm,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
Source:
mBio
Optimizing the refinement of merohedrally twinned P61 HIV-1 protease-inhibitor cocrystal structures
Friday, March 06, 2020
Author(s):
Gordon J Lockbaum,Florian Leidner,William E Royer,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Acta crystallographica. Section D, Structural biology
Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir
Tuesday, December 24, 2019
Author(s):
Jennifer Timm,Klajdi Kosovrasti,Mina Henes,Florian Leidner,Shurong Hou,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
Source:
ACS chemical biology
Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA
Tuesday, August 20, 2019
Author(s):
William C Solomon,Wazo Myint,Shurong Hou,Tapan Kanai,Rashmi Tripathi,Nese Kurt Yilmaz,Celia A Schiffer,Hiroshi Matsuo
Source:
Nucleic acids research
HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope
Wednesday, August 07, 2019
Author(s):
Linah N Rusere,Gordon J Lockbaum,Sook-Kyung Lee,Mina Henes,Klajdi Kosovrasti,Ean Spielvogel,Ellen A Nalivaika,Ronald Swanstrom,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
Source:
Journal of medicinal chemistry
Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance
Wednesday, August 07, 2019
Author(s):
Mina Henes,Klajdi Kosovrasti,Gordon J Lockbaum,Florian Leidner,Gily S Nachum,Ellen A Nalivaika,Daniel N A Bolon,Nese Kurt Yilmaz,Celia A Schiffer,Troy W Whitfield
Source:
Biochemistry
Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints
Tuesday, August 06, 2019
Author(s):
Florian Leidner,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of chemical information and modeling
Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance
Wednesday, July 31, 2019
Author(s):
Mina Henes,Gordon J Lockbaum,Klajdi Kosovrasti,Florian Leidner,Gily S Nachum,Ellen A Nalivaika,Sook-Kyung Lee,Ean Spielvogel,Shuntai Zhou,Ronald Swanstrom,Daniel N A Bolon,Nese Kurt Yilmaz,Celia A Sch...
Source:
ACS chemical biology
NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations
Friday, June 28, 2019
Author(s):
Rieko Ishima,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of biomolecular NMR
Correction to Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease
Wednesday, April 17, 2019
Author(s):
Gordon J Lockbaum,Florian Leidner,Linah N Rusere,Mina Henes,Klajdi Kosovrasti,Gily S Nachum,Ellen A Nalivaika,Daniel N A Bolon,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
Source:
ACS infectious diseases
Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease
Friday, December 14, 2018
Author(s):
Gordon J Lockbaum,Florian Leidner,Linah N Rusere,Mina Henes,Klajdi Kosovrasti,Gily S Nachum,Ellen A Nalivaika,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
Source:
ACS infectious diseases
Structural Analysis of the Active Site and DNA Binding of Human Cytidine Deaminase APOBEC3B
Wednesday, November 21, 2018
Author(s):
Shurong Hou,Tania V Silvas,Florian Leidner,Ellen A Nalivaika,Hiroshi Matsuo,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of chemical theory and computation
HIV-1 Protease Uses Bi-Specific S2/S2' Subsites to Optimize Cleavage of Two Classes of Target Sites
Sunday, November 11, 2018
Author(s):
Marc Potempa,Sook-Kyung Lee,Nese Kurt Yilmaz,Ellen A Nalivaika,Amy Rogers,Ean Spielvogel,Charles W Carter,Celia A Schiffer,Ronald Swanstrom
Source:
Journal of molecular biology
Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody
Friday, November 02, 2018
Author(s):
Kristina L Prachanronarong,Aneth S Canale,Ping Liu,Mohan Somasundaran,Shurong Hou,Yu-Ping Poh,Thomas Han,Quan Zhu,Nicholas Renzette,Konstantin B Zeldovich,Timothy F Kowalik,Nese Kurt-Yilmaz,Jeffrey D ...
Source:
Journal of virology
Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease
Tuesday, August 28, 2018
Author(s):
Ashley N Matthew,Florian Leidner,Alicia Newton,Christos J Petropoulos,Wei Huang,Akbar Ali,Nese KurtYilmaz,Celia A Schiffer
Source:
Structure (London, England : 1993)
Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants
Tuesday, July 24, 2018
Author(s):
Linah N Rusere,Ashley N Matthew,Gordon J Lockbaum,Muhammad Jahangir,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
Source:
ACS medicinal chemistry letters
T cell epitope engineering: an avian H7N9 influenza vaccine strategy for pandemic preparedness and response
Wednesday, July 18, 2018
Author(s):
Leonard Moise,Bethany M Biron,Christine M Boyle,Nese Kurt Yilmaz,Hyesun Jang,Celia Schiffer,Ted M Ross,William D Martin,Anne S De Groot
Source:
Human vaccines & immunotherapeutics
Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions
Wednesday, May 16, 2018
Author(s):
Tania V Silvas,Shurong Hou,Wazo Myint,Ellen Nalivaika,Mohan Somasundaran,Brian A Kelch,Hiroshi Matsuo,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Scientific reports
Hydration Structure and Dynamics of Inhibitor-Bound HIV-1 Protease
Saturday, March 24, 2018
Author(s):
Florian Leidner,Nese Kurt Yilmaz,Janet Paulsen,Yves A Muller,Celia A Schiffer
Source:
Journal of chemical theory and computation
Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by Nuclear Magnetic Resonance
Tuesday, February 20, 2018
Author(s):
Shahid N Khan,John D Persons,Janet L Paulsen,Michel Guerrero,Celia A Schiffer,Nese Kurt-Yilmaz,Rieko Ishima
Source:
Biochemistry
Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope
Saturday, December 16, 2017
Author(s):
Yuval Avnir,Kristina L Prachanronarong,Zhen Zhang,Shurong Hou,Eric C Peterson,Jianhua Sui,Hatem Zayed,Vinodh B Kurella,Andrew T McGuire,Leonidas Stamatatos,Brendan J Hilbert,Markus-Frederik Bohn,Timot...
Source:
Cell reports
Mavyret: A Pan-Genotypic Combination Therapy for the Treatment of Hepatitis C InfectionPublished as part of the Biochemistry series "Biochemistry to Bedside"
Saturday, December 02, 2017
Author(s):
Ashley N Matthew,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Biochemistry
Elucidating the Interdependence of Drug Resistance from Combinations of Mutations
Saturday, September 16, 2017
Author(s):
Debra A Ragland,Troy W Whitfield,Sook-Kyung Lee,Ronald Swanstrom,Konstantin B Zeldovich,Nese Kurt-Yilmaz,Celia A Schiffer
Source:
Journal of chemical theory and computation
Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants
Friday, June 09, 2017
Author(s):
Ashley N Matthew,Jacqueto Zephyr,Caitlin J Hill,Muhammad Jahangir,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt-Yilmaz,Celia A Schiffer,Akbar Ali
Source:
Journal of medicinal chemistry
Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity
Saturday, April 29, 2017
Author(s):
Takahide Kouno,Tania V Silvas,Brendan J Hilbert,Shivender M D Shandilya,Markus F Bohn,Brian A Kelch,William E Royer,Mohan Somasundaran,Nese Kurt Yilmaz,Hiroshi Matsuo,Celia A Schiffer
Source:
Nature communications
Interdependence of Inhibitor Recognition in HIV-1 Protease
Friday, March 31, 2017
Author(s):
Janet L Paulsen,Florian Leidner,Debra A Ragland,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of chemical theory and computation
Dengue Virus NS2B/NS3 Protease Inhibitors Exploiting the Prime Side
Friday, March 17, 2017
Author(s):
Kuan-Hung Lin,Akbar Ali,Linah Rusere,Djade I Soumana,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of virology
Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase
Wednesday, December 14, 2016
Author(s):
Kristina L Prachanronarong,Ayşegül Özen,Kelly M Thayer,L Safak Yilmaz,Konstantin B Zeldovich,Daniel N Bolon,Timothy F Kowalik,Jeffrey D Jensen,Robert W Finberg,Jennifer P Wang,Nese Kurt-Yilmaz,Celia A...
Source:
Journal of chemical theory and computation
Structural and molecular analysis of a protective epitope of Lyme disease antigen OspA and antibody interactions
Saturday, November 19, 2016
Author(s):
Shivender Shandilya,Nese Kurt Yilmaz,Andrew Sadowski,Ejemel Monir,Zachary A Schiller,William D Thomas,Mark S Klempner,Celia A Schiffer,Yang Wang
Source:
Journal of molecular recognition : JMR
Dengue Protease Substrate Recognition: Binding of the Prime Side
Friday, September 23, 2016
Author(s):
Kuan-Hung Lin,Ellen A Nalivaika,Kristina L Prachanronarong,Nese Kurt Yilmaz,Celia A Schiffer
Source:
ACS infectious diseases
Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease
Friday, August 12, 2016
Author(s):
Djadé I Soumana,Nese Kurt Yilmaz,Akbar Ali,Kristina L Prachanronarong,Celia A Schiffer
Source:
Journal of the American Chemical Society
Improving Viral Protease Inhibitors to Counter Drug Resistance
Wednesday, April 20, 2016
Author(s):
Nese Kurt Yilmaz,Ronald Swanstrom,Celia A Schiffer
Source:
Trends in microbiology
Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172
Sunday, December 20, 2015
Author(s):
Djadé I Soumana,Nese Kurt Yilmaz,Kristina L Prachanronarong,Cihan Aydin,Akbar Ali,Celia A Schiffer
Source:
ACS chemical biology
The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization
Tuesday, April 28, 2015
Author(s):
Markus-Frederik Bohn,Shivender M D Shandilya,Tania V Silvas,Ellen A Nalivaika,Takahide Kouno,Brian A Kelch,Sean P Ryder,Nese Kurt-Yilmaz,Mohan Somasundaran,Celia A Schiffer
Source:
Structure (London, England : 1993)
Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease
Friday, October 31, 2014
Author(s):
Ayşegül Özen,Kuan-Hung Lin,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Proceedings of the National Academy of Sciences of the United States of America
Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease
Wednesday, August 20, 2014
Author(s):
Yufeng Cai,Wazo Myint,Janet L Paulsen,Celia A Schiffer,Rieko Ishima,Nese Kurt Yilmaz
Source:
Journal of chemical theory and computation
Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease
Wednesday, August 06, 2014
Author(s):
Debra A Ragland,Ellen A Nalivaika,Madhavi N L Nalam,Kristina L Prachanronarong,Hong Cao,Rajintha M Bandaranayake,Yufeng Cai,Nese Kurt-Yilmaz,Celia A Schiffer
Source:
Journal of the American Chemical Society
Burial of nonpolar surface area and thermodynamic stabilization of globins as a function of chain elongation
Wednesday, April 23, 2014
Author(s):
Theodore S Jennaro,Matthew R Beaty,Neşe Kurt-Yilmaz,Benjamin L Luskin,Silvia Cavagnero
Source:
Proteins
HIV-1 protease-substrate coevolution in nelfinavir resistance
Friday, April 11, 2014
Author(s):
Madhavi Kolli,Ayşegül Ozen,Nese Kurt-Yilmaz,Celia A Schiffer
Source:
Journal of virology
Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance
Tuesday, September 10, 2013
Author(s):
Madhavi N L Nalam,Akbar Ali,G S Kiran Kumar Reddy,Hong Cao,Saima G Anjum,Michael D Altman,Nese Kurt Yilmaz,Bruce Tidor,Tariq M Rana,Celia A Schiffer
Source:
Chemistry & biology
Sub-millisecond chain collapse of the Escherichia coli globin ApoHmpH
Wednesday, June 12, 2013
Author(s):
Li Zhu,Neşe Kurt,Jennifer Choi,Lisa J Lapidus,Silvia Cavagnero
Source:
The journal of physical chemistry. B
Electrostatic effect of the ribosomal surface on nascent polypeptide dynamics
Saturday, March 23, 2013
Author(s):
Anders M Knight,Peter H Culviner,Neşe Kurt-Yilmaz,Taisong Zou,S Banu Ozkan,Silvia Cavagnero
Source:
ACS chemical biology
Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50
Friday, February 01, 2013
Author(s):
Seema Mittal,Rajinthna M Bandaranayake,Nancy M King,Moses Prabu-Jeyabalan,Madhavi N L Nalam,Ellen A Nalivaika,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of virology
Cooperative effects of drug-resistance mutations in the flap region of HIV-1 protease
Friday, December 21, 2012
Author(s):
Jennifer E Foulkes-Murzycki,Christina Rosi,Nese Kurt Yilmaz,Robert W Shafer,Celia A Schiffer
Source:
ACS chemical biology
Differential Flap Dynamics in Wild-type and a Drug Resistant Variant of HIV-1 Protease Revealed by Molecular Dynamics and NMR Relaxation
Tuesday, November 13, 2012
Author(s):
Yufeng Cai,Nese Kurt Yilmaz,Wazo Myint,Rieko Ishima,Celia A Schiffer
Source:
Journal of chemical theory and computation
Extreme entropy-enthalpy compensation in a drug-resistant variant of HIV-1 protease
Thursday, June 21, 2012
Author(s):
Nancy M King,Moses Prabu-Jeyabalan,Rajintha M Bandaranayake,Madhavi N L Nalam,Ellen A Nalivaika,Ayşegül Özen,Türkan Haliloğlu,Neşe Kurt Yilmaz,Celia A Schiffer
Source:
ACS chemical biology
High-resolution conformation and backbone dynamics of a soluble aggregate of apomyoglobin119
Wednesday, February 02, 2011
Author(s):
Senapathy Rajagopalan,Neşe Kurt,Silvia Cavagnero
Source:
Biophysical journal
Effects of epilepsy and antiepileptic drugs on nitric oxide, lipid peroxidation and xanthine oxidase system in children with idiopathic epilepsy
Tuesday, November 30, 2010
Author(s):
Ebru Arhan,Ayse Serdaroglu,Bahadır Ozturk,H Serdar Ozturk,Aysima Ozcelik,Nese Kurt,Ebru Kutsal,Neriman Sevinc
Source:
Seizure
Neonate with meroacrania: radiological findings and review of the literature
Friday, November 13, 2009
Author(s):
Hanefi Yildirim,Mustafa Koç,Neşe Kurt,Hakan Artaş,Denizmen Aygün
Source:
Diagnostic and interventional radiology (Ankara, Turkey)
Use of phototherapy for neonatal hyperbilirubinemia affects cytokine production and lymphocyte subsets
Friday, November 14, 2008
Author(s):
Abdullah Kurt,A Denizmen Aygun,A Nese Citak Kurt,Ahmet Godekmerdan,Saadet Akarsu,Erdal Yilmaz
Source:
Neonatology
Nonrandom distribution of intramolecular contacts in native single-domain proteins
Friday, October 03, 2008
Author(s):
Bryan C Mounce,Neşe Kurt,Paul A Ellison,Silvia Cavagnero
Source:
Proteins
A prospective study of etiology of childhood acute bacterial meningitis, Turkey
Saturday, July 05, 2008
Author(s):
Mehmet Ceyhan,Inci Yildirim,Paul Balmer,Ray Borrow,Bunyamin Dikici,Mehmet Turgut,Nese Kurt,Aysel Aydogan,Cigdem Ecevit,Yasar Anlar,Ozlem Gulumser,Gonul Tanir,Nuran Salman,Nezahat Gurler,Nevin Hatipogl...
Source:
Emerging infectious diseases
Residue-specific contact order and contact breadth in single-domain proteins: implications for folding as a function of chain elongation
Tuesday, May 13, 2008
Author(s):
Neşe Kurt,Bryan C Mounce,Paul A Ellison,Silvia Cavagnero
Source:
Biotechnology progress
The levels of Ghrelin, TNF-alpha, and IL-6 in children with cyanotic and acyanotic congenital heart disease
Saturday, February 16, 2008
Author(s):
Erdal Yilmaz,Bilal Ustundag,Yasar Sen,Saadet Akarsu,A Nese citak Kurt,Yasar Dogan
Source:
Mediators of inflammation
Serum IL-1beta, IL-6, IL-8, and TNF-alpha levels in early diagnosis and management of neonatal sepsis
Saturday, February 16, 2008
Author(s):
A Nese Citak Kurt,A Denizmen Aygun,Ahmet Godekmerdan,Abdullah Kurt,Yasar Dogan,Erdal Yilmaz
Source:
Mediators of inflammation
Nonnative helical motif in a chaperone-bound protein fragment
Tuesday, January 15, 2008
Author(s):
Neşe Kurt,Silvia Cavagnero
Source:
Biophysical journal
Thermodynamic and kinetic characterization of apoHmpH, a fast-folding bacterial globin
Saturday, January 12, 2008
Author(s):
Ye-Jin Eun,Neşe Kurt,Ashok Sekhar,Silvia Cavagnero
Source:
Journal of molecular biology
Age-specific seroprevalence of serogroup C meningococcal serum bactericidal antibody activity and serogroup A, C, W135 and Y-specific IgG concentrations in the Turkish population during 2005
Tuesday, August 21, 2007
Author(s):
Mehmet Ceyhan,Inci Yildirim,Paul Balmer,Christine Riley,Gouri Laher,Nick Andrews,Ray Borrow,Nese Kurt,Mehmet Turgut,Aysel Aydogan,Cigdem Ecevit,Gulnar Uysal,Viola Schultze
Source:
Vaccine
Serum endothelin-1 and transforming growth factor-beta levels in the newborns with respiratory distress
Friday, March 30, 2007
Author(s):
Derya Benzer,A Denizmen Aygun,Ahmet Godekmerdan,A Nese Citak Kurt,Saadet Akarsu,Erdal Yilmaz
Source:
Mediators of inflammation
Malignant infantile osteopetrosis: a rare cause of neonatal hypocalcemia
Saturday, January 27, 2007
Author(s):
Abdullah Kurt,Yasar Sen,Ozlem Elkiran,Saadet Akarsu,A Nese Citak Kurt,A Denizmen Aygun
Source:
Journal of pediatric endocrinology & metabolism : JPEM
Binding specificity of an alpha-helical protein sequence to a full-length Hsp70 chaperone and its minimal substrate-binding domain
Thursday, November 16, 2006
Author(s):
Carolina A Vega,Neşe Kurt,Zhongjing Chen,Stefan Rüdiger,Silvia Cavagnero
Source:
Biochemistry
Secondary structure mapping of DnaK-bound protein fragments: chain helicity and local helix unwinding at the binding site
Wednesday, October 04, 2006
Author(s):
Zhongjing Chen,Nese Kurt,Senapathy Rajagopalan,Silvia Cavagnero
Source:
Biochemistry
Effect of hsp70 chaperone on the folding and misfolding of polypeptides modeling an elongating protein chain
Tuesday, November 29, 2005
Author(s):
Neşe Kurt,Senapathy Rajagopalan,Silvia Cavagnero
Source:
Journal of molecular biology
The burial of solvent-accessible surface area is a predictor of polypeptide folding and misfolding as a function of chain elongation
Thursday, November 10, 2005
Author(s):
Neşe Kurt,Silvia Cavagnero
Source:
Journal of the American Chemical Society
Structural characterization of apomyoglobin self-associated species in aqueous buffer and urea solution
Tuesday, October 11, 2005
Author(s):
Charles Chow,Nese Kurt,Regina M Murphy,Silvia Cavagnero
Source:
Biophysical journal
The differential diagnostic values of cytokine levels in pleural effusions
Thursday, March 17, 2005
Author(s):
Saadet Akarsu,A Nese Citak Kurt,Yasar Dogan,Erdal Yilmaz,Ahmet Godekmerdan,A Denizmen Aygun
Source:
Mediators of inflammation
Bilateral symmetrical hypodensities in the thalamus in a child with severe hypernatraemia
Saturday, March 12, 2005
Author(s):
Huseyin Ozdemir,Nimet Kabakus,A Nese Cýtak Kurt,Hakan Artas
Source:
Pediatric radiology
Antibiotic resistance of bacterial agents isolated in a neonatal intensive care unit in eastern Turkey
Tuesday, April 20, 2004
Author(s):
Erdal Taskin,Mehmet Kilic,A Denizmen Aygun,Saadet Akarsu,A Neşe Kurt
Source:
Journal of tropical pediatrics
Structure-based prediction of potential binding and nonbinding peptides to HIV-1 protease
Wednesday, July 30, 2003
Author(s):
Nese Kurt,Turkan Haliloglu,Celia A Schiffer
Source:
Biophysical journal
Cooperative fluctuations of unliganded and substrate-bound HIV-1 protease: a structure-based analysis on a variety of conformations from crystallography and molecular dynamics simulations
Wednesday, April 16, 2003
Author(s):
Nese Kurt,Walter R P Scott,Celia A Schiffer,Turkan Haliloglu
Source:
Proteins
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