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Platelets and Respiratory Viruses

Mechanisms of recognizing and sensing respiratory viruses in platelets

Platelets are central in mediating hemostasis and thrombosis and have also been recognized for mediating an immune response during infection with various pathogens. Human platelets internalize respiratory viruses such as influenza and SARS-CoV-2, do not get infected but become activated. Utilizing blood from human donors and various murine models, research in our lab aims to understand the molecular mechanisms by which platelets internalize respiratory viruses and become activities. A central theme is focused on the description of pathogen associated molecular pattern receptors and signaling cascades that underline the immune response to infection and how the this response can contribute to immunothrombosis.