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Study of an Investigational Drug to Reduce HS Inflammation

Study PI: Sarah Whitley, MD, PhD
Sponsors: AbbVie

A Phase 3, randomized, placebo-controlled, double-blind study to evaluate efficacy and safety of upadacitinib in adult and adolescent subjects with moderate to severe hidradenitis suppurativa who have failed anti-TNF therapy’.


Participants in this study will either get injected with the investigational drug or a placebo (looks like the drug but contains no medicine) approximately every 2 weeks over 12 weeks. Over the 1 year study period there will be up to 12 clinic visits.


Inclusion Criteria

  • ≥ 12 years old
  • Moderate-severe active HS
  • Previous use of ≥ 1 TNF inhibitor for HS for at least 12 weeks and/or 1 approved non-anti-TNF biologic therapy for HS for at least 16 weeks characterized by inadequate response or intolerance.

Exclusion Criteria

  • Pregnant or breastfeeding
  • Treatment with immunomodulatory biologic therapy for any indication within the prior 8-16 weeks
  • Active infection.