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The HS Hub: Your Resource for Understanding Hidradenitis Suppurativa

New Hope for Hidradenitis Suppurativa: FDA Approves Cosentyx

Monday, May 20, 2024

The U.S. Food and Drug Administration (FDA) recently announced the approval of Cosentyx (secukinumab), developed by Novartis, for the treatment of moderate to severe hidradenitis suppurativa (HS) in adults. This marks a significant development for individuals struggling with this chronic and debilitating skin condition.

What is Cosentyx and how does it work?

Cosentyx belongs to a class of medications called fully human biologics. These drugs target specific components of the immune system involved in disease processes. In the case of HS, Cosentyx works by inhibiting interleukin-17A (IL-17A), a molecule known to play a key role in the inflammation associated with HS.

Treatment with Cosentyx

The approved dosage for HS is 300mg administered every four weeks. Depending on individual response, the frequency can be adjusted to every two weeks. This flexibility allows for personalized treatment plans based on each patient's needs.

The data behind the approval

The FDA's decision is backed by data collected from the Phase III SUNSHINE and SUNRISE clinical trials in HS. These studies demonstrated that a significantly greater proportion of patients treated with Cosentyx (either every two or four weeks) achieved a hidradenitis suppurativa clinical response compared to those receiving a placebo.

Encouraging signs

The research also revealed that Cosentyx's therapeutic effects begin to show as early as week two, with efficacy progressively increasing until week 16 and sustained through week 52. This suggests the potential for Cosentyx to offer meaningful and lasting relief for HS patients.

Looking ahead

The approval of Cosentyx represents a valuable addition to the treatment options available for individuals living with HS. This new therapy provides hope for improved disease management and a better quality of life for countless patients.

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