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Program Contacts

Phone: 7744553694
Email: kristen.yanick@umassmed.edu

Robert Brewster, PhD

Robert C. Brewster, PhD

Associate Professor, Department in Systems Biology and Department of Microbiology and Physiological Systems

Dissecting and Understanding the Implications of Resource Sharing to Cellular Decision Making
My group studies transcriptional regulation in bacteria through a combination of theory, using molecularly detailed statistical mechanics models to produce quantitative predictions, and the tools of modern synthetic biology to design and test these predictions using a wide range of microscopy techniques. In particular, I am interested in understanding how the interconnected environment of the cell, where most regulatory players (transcription factor proteins, regulatory RNAs, etc.) act on dozens or even hundreds of different genes, can influence the special and temporal patterns of gene expression

Brewster Lab Website ››

Hyun Youk, PhD

Hyun Youk, PhD

Associate Professor, Department of Systems Biology and Program in Molecular Medicine

Transitions Between Being Alive and Being Truly or Seemingly Dead
We are interested in identifying and studying the ways in which a cell or an organism transitions between being alive and being either truly or seemingly dead (e.g., dormancy). We hope to find common principles that underlie these transitions. We are particularly interested in principles that allow life to be restarted after it has nearly or completely ceased, as in the case of dormant spores in yeast and diapaused mouse embryos. Our studies can deepen our understanding of quiescent and senescent cells which, in turn, are important for understanding human diseases such as cancer and how and why organisms age. We use quantitative experiments that range from single-cell-level measurements on microscopes to transcriptome analyses.

Youk Lab Website ››

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