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Scot A. Wolfe, PhD

Research Focus - Therapeutic Genome Editing Systems

  • Application of novel Cas9/Cas12a-based genome editing systems
  • Use of therapeutic genome editing for β-hemoglobinopathies and other hematopoietic disorders  
  • Use of therapeutic genome editing for muscular dystrophies 
  • Development of delivery approaches for somatic cell genome editing
  • Development of artificial zinc finger-based transcriptional regulators 

Representative Publication

Iyer S, Suresh S, Guo D, et al. Precise therapeutic gene correction by a simple nuclease-induced double-strand break. Nature. 2019;568(7753):561-565.

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In the News

Getting Results…
  • Science for Living: Scot Wolfe explains revolutionary CRISPR gene-editing treatment

    Science for Living: Scot Wolfe explains revolutionary CRISPR gene-editing treatment

     A UMass Chan professor of molecular, cell & cancer biology explains the science behind CRISPR/Cas9 gene-editing technology, following the FDA’s first approval of a gene-editing treatment for sickle cell disease.

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  • Erik Sontheimer co-leading efforts to develop gene editing toolkit by NIH Somatic Cell Genome Editing Consortium

    Erik Sontheimer co-leading efforts to develop gene editing toolkit by NIH Somatic Cell Genome Editing Consortium

    Six UMass Medical School scientists are among the members of the National Institutes of Health’s Somatic Cell Genome Editing Consortium to publish a paper in Nature outlining the program’s goals.

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