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Michael J. Lee, PhD

Research Focus - Cancer Systems Pharmacology

  • Computational design of anticancer drug combinations
  • Use of genetic screening to understand mechanisms of regulated cell death
  • Examination of the mechanisms of interaction between apoptotic and non-apoptotic death
  • Characterization of the mechanisms of drug resistance
  • Modeling of signaling pathway circuitry in the DNA damage response

Representative Publication

Landry BD, Leete T, Richards R, et al. Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells. Mol Syst Biol. 2018;14(8):e8322.

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In the News

Getting Results…
  • PhD candidate to use NIH award to study cell death in cancer patients

    PhD candidate to use NIH award to study cell death in cancer patients

    Nicholas Harper, a PhD candidate in the Interdisciplinary Graduate Program, has received a prestigious award from the National Cancer Institute to study cell death as it relates to cancer therapies.

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  • PhD student Megan Honeywell receives prestigious Ruth L. Kirschstein Predoctoral award

    PhD student Megan Honeywell receives prestigious Ruth L. Kirschstein Predoctoral award

    In her preliminary studies, PhD student Megan Honeywell has found that cells can trigger a cell death even when they do not have the p53 protein, the so-called “guardian of the genome.”

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