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A.J. Marian Walhout, PhD

Research Focus - Worms and Bugs: A Model for Cancer and Chemotherapeutic Drug Response

  • Use of C. elegans and its bacterial diet as a model for dietary effects on cancer-related metabolism
  • Characterization of the effects of the microbiome on chemotherapeutic drug response
  • Study of the influence of gut microbiota on chemotherapeutic drug side effects
  • Identification of factors and pathways targeted by the oncometabolite 2-hydroxyglutarate

Representative Publication

García-González AP, Ritter AD, Shrestha S, et al. Bacterial metabolism affects the C. elegans response to cancer chemotherapeutics Cell. 2017;169(3):431-441.

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In the News

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  • UMass Chan researchers identify molecular link between gut bacteria and excitatory brain signaling in C. elegans

    UMass Chan researchers identify molecular link between gut bacteria and excitatory brain signaling in C. elegans

    A new study published in Nature Cell Biology by Mark Alkema, PhD, establishes an important molecular link between specific B12-producing bacteria in the gut of the roundworm C. elegans and the production of a neurotransmitter important to memory and cognitive function.

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  • Chancellor Collins: Momentum high at UMass Chan after year of milestone accomplishments

    Chancellor Collins: Momentum high at UMass Chan after year of milestone accomplishments

    In his annual Convocation address to the UMass Chan Medical School community on Thursday, Sept. 16, Chancellor Michael F. Collins expressed optimism for the Medical School’s ambitious future and touted the enormous momentum moving the school forward.

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  • Heat shot of Albertha J.M. "Marian" Walhout taken at UMass Chan Medical School in 2021.

    Collaborative effort led by Marian Walhout spotlights worms as model for personalized medicine

    UMass Chan researcher Marian Walhout, PhD, along with collaborators at Northwestern and Cornell, have developed an animal model system to interrogate individual differences in metabolism.

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  • Heat shot of Albertha J.M. "Marian" Walhout taken at UMass Chan Medical School in 2021.

    UMass Chan Medical School establishes new Department of Systems Biology

    The Program in Systems Biology has been elevated to full department status, with Marian Walhout, PhD, serving as the founding chair of the Department of Systems Biology.

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