Search the Cancer Center site

Home
About
About

Located in Worcester, Massachusetts, the UMass Cancer Center is committed to providing exceptional patient care, conducting cutting-edge research at the highest level, offering excellence in education and training, and serving as an educational resource and advocate for the Central Massachusetts community.
Patients
Patients

Expert Cancer Care in Central Massachusetts

We offer comprehensive cancer care for all childhood and adult cancers, combining state-of-the-art treatments with compassionate support for patients and their families.
Members
Clinicians
Research
Research

Cutting-Edge Cancer Research

We carry out front-line research in basic, translational, clinical and population-based discovery to find newer, better methods for the prevention, detection, diagnosis, and treatment of cancer.
Education
Education

World Class Medical and Scientific Education

The UMass Cancer Center is dedicated to training the next generation of cancer researchers, clinicians and physician-scientists.
Outreach
Michael Green Memorial
Michael Green Memorial

UMass Chan lost one of its greats when Michael R. Green, MD, PhD, passed away unexpectedly in February 2023. We've established these web pages in his memory so our visitors can take a few minutes, from time to time, to peruse and remember him.

Donate to the The Michael R. Green, MD, PhD, Award in Graduate Research:

Donate

Additional Resources

Louis M. Messina, MD

Professor and Vice Chair of Research, Department of Surgery; The Johnnie Ray Cox Term Chair in Biomedical Research, UMass Chan Medical School

Website

Page Menu

Louis M. Messina, MD

Research Focus - Hematopoietic Stem Cell-Based Cancer Immunotherapy

Study of how hypercholesterolemia impairs colorectal cancer immunosurveillance by an oxidant stress-dependent hematopoietic stem cell (HSC)-autonomous mechanism that reduces the number and function of natural killer T (NKT) and gamma delta (γδ) T cells
Development of an HSC-Tet1-dependent NKT and γδ T cell-based cancer immunotherapy
Exploration of how physical activity lowers breast cancer incidence by reducing HSC-oxidant stress

Representative Publication

Tie G, Yan J, Khair L, et al. Hypercholesterolemia increases colorectal cancer incidence by reducing production of NKT and γδ T cells from hematopoietic stem cells. Cancer Res. 2017;77(9):2351-2362.

Read Publication

More Publications