Jennifer Benanti, PhD

Research Focus - Cell Cycle Regulation

• Understanding the wiring of the cell cycle-regulatory network that controls the proliferation of normal cells and how this network is disrupted in cancer cells
• Examining phosphoregulation of the transcription factor network that controls expression of cell cycle-regulated genes
• Identifying ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) that control degradation of cell cycle-regulatory proteins
• Elucidating the ways in which the cell cycle-regulatory network is rewired when cells are exposed to environmental stress

Representative Publication

Landry BD, Mapa CE, Arsenault HE, Poti KE, Benanti JA. Regulation of a transcription factor network by Cdk1 coordinates late cell cycle gene expression. EMBO J. 2014;33(9):1044-1060.

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