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Athma Pai, PhD

Research Focus - The Efficiency of mRNA Splicing Regulation in Cancer

  • Exploring the kinetics of mRNA splicing regulation.
  • Investigating the tradeoff between temporal specificity and splice site fidelity in mis-regulated gene expression programs.
  • Understanding the functional consequences of recurrent cancer-associated mutations in core splicing regulatory factors.
  • Developing novel genomic approaches for measuring the temporal coordination between disparate steps of mRNA processing.

Representative Publication

Pai AA, Luca F. Environmental influences on RNA processing: Biochemical, molecular and genetic regulators of cellular response. Wiley Interdiscip Rev RNA. 2019 Jan;10(1):e1503.

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In the News

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  • PhD student Valeria Sanabria wins Zelda Haidak Scholarship in Cell Biology

    PhD student Valeria Sanabria wins Zelda Haidak Scholarship in Cell Biology

    PhD student Valeria Sanabria, MD, won the Zelda Haidak Scholarship in Cell Biology, which was established to enhance training for women pursuing research careers in cell biology. Her research is focused on studying gene expression at the transcriptional level.

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  • UMass Chan, Moderna partner to provide microscopes to Worcester middle schools

    UMass Chan, Moderna partner to provide microscopes to Worcester middle schools

    Dozens of new microscopes will be delivered to six Worcester middle schools thanks to a partnership between UMass Chan Medical School and Moderna.

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  • Athma Pai awarded NSF CAREER grant

    Athma Pai awarded National Science Foundation CAREER grant

    Athma A. Pai, PhD, was awarded a nearly $1 million CAREER grant from the National Science Foundation to use new high-throughput genomics approaches to study the regulation of mRNA splicing.

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  • UMass Chan partners with Worcester to outfit elementary students with backpacks and school supplies

    UMass Chan partners with Worcester to outfit elementary students with backpacks and school supplies

    Nearly 600 students in Worcester received backpacks filled with school supplies this week, thanks to the UMass Chan Medical School community.

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  • Emma RNA Saves the Day coloring book helps children understand how COVID-19 vaccines work

    Emma RNA Saves the Day coloring book helps children understand how COVID-19 vaccines work

    A coloring book created by a team at UMass Chan Medical School is helping children learn about the SARS-CoV-2 virus that causes COVID-19 and the RNA vaccines that protect against it.

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  • Remillard Family Community Service Fund awards nine grants for UMass Chan collaborations

    Remillard Family Community Service Fund awards nine grants for UMass Chan collaborations

    Funded projects led by faculty, students, staff and community partners have the potential to improve the health of Central Massachusetts residents, particularly those who are economically or educationally disadvantaged or underrepresented.

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  • Worcester elementary students greeted with supply-filled backpacks from UMass Medical School

    Worcester elementary students greeted with supply-filled backpacks from UMass Medical School

    Nearly 600 backpacks were distributed to students at Rice Square, Grafton Street and Union Square elementary schools thanks to the UMass Medical School North Quadrant Support Services partnership with the Worcester Public Schools.

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  • Interactive virtual ScienceLIVE program builds in Worcester schools

    Interactive virtual ScienceLIVE program builds in Worcester schools

    An interactive online science program for middle school students developed and presented by UMass Medical School researchers will deepen its partnership with Worcester Public Schools this fall.

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  • ScienceLIVE brings virtual labs to area middle school students

    ScienceLIVE brings virtual labs to area middle school students

    UMass Medical School’s RNA Therapeutics Institute and Sanderson Center for Optical Experimentation have partnered with Technocopia Inc., a nonprofit community makerspace in downtown Worcester, to develop ScienceLIVE, a virtual outreach program to deliver science to middle school students during the pandemic.

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