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Arthur M. Mercurio, PhD

Research Focus - Cell Biology of Aggressive Carcinomas: Mechanisms and Therapy

  • Examination of mechanisms that sustain cancer stem cells (CSCs)
  • Characterization of non-cell autonomous regulation of CSCs
  • Understanding the role of integrins and the extracellular matrix in CSCs and aggressive behavior
  • Elucidation of the non-angiogenic functions of vascular endothelial growth factor (VEGF) and its receptors (neuropilins) on CSCs
  • Therapeutic targeting of neuropilins
  • Study of the cell biology of ferroptosis and development of its therapeutic potential

Representative Publication

Brown CW, Chhoy P, Mukhopadhyay D, et al. Targeting prominin2 transcription to overcome ferroptosis resistance in cancer. EMBO Mol Med. 2021;13(8):e13792.

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In the News

Getting Results…
  • UMass Chan MD/PhD student Ayush Kumar wins AMA Research Challenge

    UMass Chan MD/PhD student Ayush Kumar wins AMA Research Challenge

    More than 1,330 research projects were submitted to the 2024 AMA Research Challenge for consideration.

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  • UMass Chan scientist seeks to overcome resistance to radiation therapy for breast cancer patients

    UMass Chan scientist seeks to overcome resistance to radiation therapy for breast cancer patients

    Research aimed at identifying the mechanisms that promote resistance to radiation therapy in patients with triple negative breast cancer is underway at UMass Chan Medical School by Arthur M. Mercurio, PhD, thanks to a new $2.6 million cancer research award from the National Institutes of Health.

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  • NIH funds MD/PhD student’s research on triple-negative breast cancer

    NIH funds MD/PhD student’s research on triple-negative breast cancer

    MD/PhD student Ayush Kumar has received a Ruth L. Kirschstein National Research Award from the National Cancer Institute to study the most aggressive type of breast cancer.

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  • PhD student studies cancer tumor cells; follows path of high school science teacher

    PhD student studies cancer tumor cells; follows path of high school science teacher

    Emmet Karner, a PhD student in the Morningside Graduate School of Biomedical Sciences, was inspired by a passionate and influential teacher to go into the field.

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