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William A. Flavahan, PhD

Research Focus - Epigenetics and Chromatin Topology in Cancer

  • Identify epigenetic driver lesions in cancer
  • Develop and utilize tools for epigenome editing
  • Characterize cancer-associated defects in the three-dimensional structure of the genome
  • Discover the effects of tumor-associated microenvironment (especially metabolism) on the epigenome
  • Develop methods to target epigenetically-driven phenotypes such as cancer stem cells and drug-tolerant persisters

Representative Publication  

Flavahan WA, Drier Y, et al. Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs. Nature. 2019;575(7781):229-233.

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  • William Flavahan receives Distinguished Scientist Award for groundbreaking brain cancer research
    Research News

    William Flavahan receives Distinguished Scientist Award for groundbreaking brain cancer research

    William Flavahan, PhD, has received a four-year, $600,000 award from the Sontag Foundation to advance his studies of the genetic processes leading to brain tumors.

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