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Victor Ambros, PhD

Research Focus - Genetic Control of Developmental Timing in C. elegans

  • Molecular basis of regulated cell fate transitions
  • Regulation of stem cell proliferation and self-renewal
  • Coordination of growth and cell fate across the animal
  • Regulation of mRNA translation by microRNAs and RNA binding proteins

Representative Publication

Nelson C, Ambros V. Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity. Development. 2019;146(5):dev172031.

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In the News

Getting Results…
  • UMass Chan study reveals new details about Argonaute syndromes, a recently identified class of neurodevelopmental disorders

    UMass Chan study reveals new details about Argonaute syndromes, a recently identified class of neurodevelopmental disorders

    Researchers have identified amino acid changes in the AGO1 protein that cause Argonaute syndrome. These genetic mutations, studied in the C. elegans model, cause an organism-wide disruption of the RNA silencing process impacting hundreds of different genes.  

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  • UMass Chan study shows how novel mechanism in P. aeruginosa bacteria disables ribosome

    UMMS study shows how novel mechanism in P. aeruginosa bacteria disables ribosome

    A new study by Alejandro Vasquez-Rifo, PhD, and Victor Ambros, PhD, shows that certain strains of Pseudomonas aeruginosa, a rod-shaped bacterial pathogen that causes disease in plants and animals, including humans, have a unique mechanism for disabling and degrading the ribosome in its host cells.

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  • Victor Ambros named fellow of the American Association for the Advancement of Science

    Victor Ambros named fellow of the American Association for the Advancement of Science

    Victor Ambros, PhD, has been elected by his peers as a fellow of the American Association for the Advancement of Science.

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