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Phillip D. Zamore, PhD

Research Focus - Understanding the Role of Argonaute Proteins in Regulating Gene Expression

  • Explore the diverse functions of Argonaute proteins across the kingdoms of life
  • Elucidate how mammalian piRNAs are produced and function
  • Identify genic and epigenetic features that destine transcripts for processing into piRNAs
  • Study how miRNAs are made and the mechanisms ensuring accurate processing of miRNA precursors
  • Use biochemical principles to predict miRNA regulation of target mRNAs

Representative Publication

Gainetdinov I, Colpan C, Arif A, Cecchini K, Zamore PD. A single mechanism of biogenesis, initiated and directed by PIWI proteins, explains piRNA production in most animals. Mol. Cell. 2018;71(15):775-790.

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