Michelle Kelliher, PhD

Research Focus - Mouse Models of T Cell Acute Lymphoblastic Leukemia

• Use of mouse models of T cell acute lymphoblastic leukemia (T-ALL) to guide leukemia drug discovery efforts by defining essential pathways and synergistic combination therapies
• Application of siRNA and CRISPR screening methods to understand disease pathogenesis and identify mechanisms of resistance
• Mapping of the leukemia microenvironment of T-ALL at the single-cell level and identification of markers/pathways that define leukemia-initiating cells
• Evaluation of the contribution of RIPK1 kinase-mediated cell death to acute and chronic inflammatory diseases, including myelodysplasia

Representative Publication

Gallagher KM, Roderick JE, Tan SH, et al. ESRRB regulates glucocorticoid gene expression in mice and patients with acute lymphoblastic leukemia. Blood Adv. 2020;4(13):3154-3168.

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