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A.J. Marian Walhout, PhD

Research Focus - Worms and Bugs: A Model for Cancer and Chemotherapeutic Drug Response

  • Use of C. elegans and its bacterial diet as a model for dietary effects on cancer-related metabolism
  • Characterization of the effects of the microbiome on chemotherapeutic drug response
  • Study of the influence of gut microbiota on chemotherapeutic drug side effects
  • Identification of factors and pathways targeted by the oncometabolite 2-hydroxyglutarate

Representative Publication

García-González AP, Ritter AD, Shrestha S, et al. Bacterial metabolism affects the C. elegans response to cancer chemotherapeutics Cell. 2017;169(3):431-441.

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  • UMass Chan Medical School establishes new Department of Systems Biology
    Research News

    UMass Chan Medical School establishes new Department of Systems Biology

    The Program in Systems Biology has been elevated to full department status, with Marian Walhout, PhD, serving as the founding chair of the Department of Systems Biology.

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