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Marcus Ruscetti, PhD

Research Focus - Harnessing Intrinsic Tumor Suppressor Pathways to Restore Anti-Tumor Immunity

  • Dissecting the transcriptional and epigenetic regulation of a tumor suppressive process known as cellular senescence in different tumor contexts
  • Harnessing the senescence-associated secretory phenotype (SASP) to reengage immune surveillance and overcome immunotherapy resistance in pancreatic cancer
  • Elucidating and targeting genetic mediators of immune escape in prostate cancer metastasis using an innovative mouse modeling approach
  • Uncovering mechanisms of resistance to RAS targeted therapies and senescence and immune surveillance bypass in lung cancer

Representative Publication

Ruscetti M, Morris JP IV, Mezzadra, R et al. Senescence-induced vascular remodeling creates therapeutic vulnerabilities in pancreas cancer. Cell 2020;181(2):424-441.

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In the News

Getting Results…
  • UMass Chan faculty present translational research at BRIDGE Fund Innovation Showcase

    UMass Chan faculty present translational research at BRIDGE Fund Innovation Showcase

    UMass Chan supports translational research from faculty with internal funding mechanism.

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  • UMass Chan researchers develop dual therapeutic that holds promise as pancreatic cancer treatment

    UMass Chan researchers develop dual therapeutic that holds promise as pancreatic cancer treatment

    UMass Chan Medical School scientists Marcus Ruscetti, PhD, and Prabhani Atukorale, PhD, have developed a new, dual immunotherapy approach that may potentially change the way clinicians treat pancreatic cancer.  

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  • UMass Chan BRIDGE Fund commits $2M in six faculty projects

    UMass Chan BRIDGE Fund commits $2M in six faculty projects

    BRIDGE Innovation and Business Development at UMass Chan Medical School has set aside nearly $2 million in funding for six faculty-led research projects that hold promise for translation to clinical application and commercialization.  

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  • PODCAST: Marcus Ruscetti shares his research journey in cancer biology

    PODCAST: Marcus Ruscetti shares his research journey in cancer biology

    Marcus Ruscetti, PhD, resisted following in his parents’ scientist footsteps but ended up in a career dedicated to cancer research in and out of the lab.

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  • Marcus Ruscetti receives American Cancer Society award for prostate cancer research

    Marcus Ruscetti receives American Cancer Society award for prostate cancer research

    The Research Scholar Grant will support Dr. Ruscetti’s research on senescent cells and their role in tumor progression and immune suppression in prostate cancer.

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  • UMass Cancer Center funds five UMass Chan research projects

    UMass Cancer Center funds five UMass Chan research projects

    The UMass Cancer Center Pilot Project Program has awarded seed grants to five UMass Chan Medical School research projects to enable investigators to gather pilot data for external cancer-focused funding.

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