Research Focus - Harnessing Intrinsic Tumor Suppressor Pathways to Restore Anti-Tumor Immunity
Dissecting the transcriptional and epigenetic regulation of a tumor suppressive process known as cellular senescence in different tumor contexts
Harnessing the senescence-associated secretory phenotype (SASP) to reengage immune surveillance and overcome immunotherapy resistance in pancreatic cancer
Elucidating and targeting genetic mediators of immune escape in prostate cancer metastasis using an innovative mouse modeling approach
Uncovering mechanisms of resistance to RAS targeted therapies and senescence and immune surveillance bypass in lung cancer
Representative Publication
Ruscetti M, Morris JP IV, Mezzadra, R et al. Senescence-induced vascular remodeling creates therapeutic vulnerabilities in pancreas cancer. Cell 2020;181(2):424-441.
UMass Cancer Center funds five UMass Chan research projects
The UMass Cancer Center Pilot Project Program has awarded seed grants to five UMass Chan Medical School research projects to enable investigators to gather pilot data for external cancer-focused funding.
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, Graduate School of Biomedical Sciences, School of Medicine, Dermatology, Medicine, Cancer Center, Thomas Fazzio, Michael R. Green, Anastasia Khvorova, John Harris, Molecular, Cell and Cancer Biology, Population and Quantitative Health Sciences, RNA Therapeutics Institute, Fazzio Lab, Rajani Sadasivam, Marcus Ruscetti, Latest News, Prabhani Atukorale, Chan Zhou, Elise Stevens,