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Leslie M. Shaw, PhD

Research Focus - Mechanisms of Breast Cancer Progression

  • Insulin signaling and the role of insulin receptor substrate (IRS) proteins in breast cancer progression
  • Structure/function analysis of IRS proteins
  • Connection between obesity and breast cancer progression
  • IRS2 function in pleomorphic invasive lobular breast cancer
  • Beclin 1 regulation of endocytic receptor trafficking and tumor progression

Representative Publication

Zhu S, Ward BM, Yu J, et al. IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma. JCI Insight. 2018;3(8):e97398.

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