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Kuang Shen, PhD

Research Focus - Biochemical Characterization of the mTORC1 Pathway

  • Study the molecular mechanism of the mTORC1 pathway
  • Utilize biophysical and biochemical tools, including cryo-EM, single molecule FRET, enzyme kinetic analysis
  • Build a quantitative network to predict consequences of mTORC1 pathway mutations

Representative Publication

Egri SB, Ouch C, Chou HT, et al. Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol Cell. 2022; 82(10):1836-1849.e5.

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