Kuang Shen, PhD
Research Focus - Biochemical Characterization of the mTORC1 Pathway
- Study the molecular mechanism of the mTORC1 pathway
- Utilize biophysical and biochemical tools, including cryo-EM, single molecule FRET, enzyme kinetic analysis
- Build a quantitative network to predict consequences of mTORC1 pathway mutations
Representative Publication
Egri SB, Ouch C, Chou HT, et al. Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol Cell. 2022; 82(10):1836-1849.e5.