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Kenneth L. Rock, MD

Research Focus - Immune Recognition and Control of Cancer

  • Study of how the death of cancer cells alerts the immune system to danger (damage-associated molecular patterns and inflammation)
  • Investigation of how immune surveillance detects cancer (dendritic cells and MHC I cross presentation)
  • Characterization of how effector T cells are able to identify cancerous cells (MHC I antigen presentation)
  • Exploration of cancer immune evasion, progression, and response to therapy

Representative Publication

Kriegsman BA, Vangala P, Chen BJ, et al. Frequent loss of IRF2 in cancers leads to immune evasion through decreased MHC class I antigen presentation and increased PD-L1 expression. J Immunol. 2019;203(7):1999-2010.

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