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Karl Simin, PhD

Research Focus - Molecular Pathways of Cancer Malignancy

  • Study of breast tumor biology in the context of pRb, p53, and Brca1 loss
  • Characterization of transcriptomic signatures of breast atypia
  • Use of transgenic mouse models of triple-negative breast cancer
  • Elucidation of Dkk and Wnt/β-catenin signaling in cancer
  • Use of patient-derived xenograft mouse models from the UMass Cancer Avatar Institute

Representative Publication

Johnson JP, Kumar P, Koulnis M, Patel M, Simin K. Crucial and novel cancer drivers in a mouse model of triple-negative breast cancer. Cancer Genomics Proteomics. 2014;11(3):115-126.

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