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Jianhan Chen, PhD

Research Focus - Sequence-Structure-Function-Disease Relationship of Intrinsically Disordered Proteins in Cancer

  • Combine simulation and experiment to understand the molecular basis of function and regulation of intrinsically disordered proteins (IDPs) involved in cancer
  • Exploit the tumor suppressor p53 as an important paradigm for studying the sequence-structure-function relationship of IDPs in cancer
  • Develop strategies to target IDPs through dynamics interactions with small molecules
  • Develop multi-scale modeling and simulation methods for studying IDP structure and interaction

Representative Publication

Ganguly D, Chen J. Modulation of the disordered conformational ensembles of the p53 transactivation domain by cancer-associated mutations. PLoS Comput Biol. 2015;11(4):e1004247.

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