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Jessica Spinelli, PhD

Research Focus - Metabolic Flexibility in the Tumor Microenvironment

  • Hypoxia and metabolic adaptations in the tumor microenvironment
  • Flexibility of ETC circuits in cancer
  • The mechanisms underlying ETC complex mutations that drive tumor growth
  • Novel mitochondrial functions in tumors

Representative Publication

Spinelli JB, Rosen PC, Sprenger HG, et al. Fumarate is a terminal electron acceptor in the mammalian electron transport chain. Science. 2021; 374(6572):1227-1237.

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In the News

Getting Results…
  • Jessica Spinelli named 2023 Searle Scholar

    Jessica Spinelli named 2023 Searle Scholar

    Jessica Spinelli, PhD, and members of her lab are leveraging the discovery of a new mammalian metabolite and mitochondrial pathway to develop tools to reprogram the electron transport chain.

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