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Jessica Spinelli, PhD

Research Focus - Metabolic Flexibility in the Tumor Microenvironment

  • Hypoxia and metabolic adaptations in the tumor microenvironment
  • Flexibility of ETC circuits in cancer
  • The mechanisms underlying ETC complex mutations that drive tumor growth
  • Novel mitochondrial functions in tumors

Representative Publication

Spinelli JB, Rosen PC, Sprenger HG, et al. Fumarate is a terminal electron acceptor in the mammalian electron transport chain. Science. 2021; 374(6572):1227-1237.

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In the News

Getting Results…
  • UMass Chan researchers receive early career awards to conduct studies on biology of aging

    UMass Chan researchers receive early career awards to conduct studies on biology of aging

    The awards are from the American Federation for Aging Research and the Glenn Foundation.

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  • Jessica Spinelli, Emma Watson named to distinguished HHMI scholars program

    Jessica Spinelli, Emma Watson named to distinguished HHMI scholars program

    Jessica Spinelli, PhD, and Emma V. Watson, PhD’16, are the first UMass Chan faculty members to receive the award.

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  • Chancellor Collins to UMass Chan PhD candidates: ‘We need your science’

    Chancellor Collins to UMass Chan PhD candidates: ‘We need your science’

    During the annual Recognition Ceremony, the Morningside Graduate School of Biomedical Sciences celebrated 74 PhD candidates and MD/PhD students who successfully completed their qualifying exam in 2024-2025.

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  • PhD student Claire Shamber awarded prestigious NSF grant to advance metabolic research

    PhD student Claire Shamber awarded prestigious NSF grant to advance metabolic research

    PhD student Claire Shamber has been awarded a National Science Foundation Graduate Research Fellowship to further her research focused on investigating the untapped.  

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  • Research by Jessica Spinelli identifies novel electron-carrying metabolite in mammals

    Research by Jessica Spinelli identifies novel electron-carrying metabolite in mammals

    Identification of the metabolite rhodoquinone as the second electron transporter may have clinical applications for treating ischemia.

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  • Jessica Spinelli named 2023 Searle Scholar

    Jessica Spinelli named 2023 Searle Scholar

    Jessica Spinelli, PhD, and members of her lab are leveraging the discovery of a new mammalian metabolite and mitochondrial pathway to develop tools to reprogram the electron transport chain.

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