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Jeanne B. Lawrence, PhD

Research Focus - Epigenetics and Cancer

  • Study of epigenetic instability in cancer
  • Examination of aberrant expression of human satellite (HSAT) in cancer
  • Characterization of the greatly increased risks of leukemia, but low incidence of solid tumors, in Down syndrome
  • Elucidation of heterochromatin regulation in cell senescence and compromise in cancer

Representative Publication

Hall LL, Byron M, Carone DM, et al. Demethylated HSATII DNA and HSATII RNA foci sequester PRC1 and MeCP2 into cancer-specific nuclear bodies. Cell Rep. 2017;18(12):2943-2956.

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