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Hong Zhang, PhD

Research Focus - Cellular Senescence in Tumorigenesis and Aging

  • Understanding the molecular regulation of cellular senescence
  • Characterizing the role of senescence in tumorigenesis
  • Elucidating the function of Smurf2 as a driver of senescence and lymphomagenesis
  • Examining the phosphorylation of Mdm2 in senescence activation in response to oxidative stress

Representative Publication

Ramkumar C, Cui H, Kong Y, Jones SN, Gerstein RM, Zhang H. Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1. Nat. Commun. 2013;4:2598.

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