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Gary Ostroff, PhD

Research Focus - Mab-Complement-Glucan-Mediated Activation of the Innate Immune System to Attack Tumor Cells

  • Examination of the role of the innate immune system in the maintenance, metastasis, and clearance of tumors
  • Use of beta 1,3-glucan as a checkpoint activator of the innate immune system to attack cell surface Mab-complement complexes on tumor cells
  • Use of, and examination of the mechanism for, beta 1,3-glucan to stimulate an M2 to M1 tumor-associated macrophage (TAM) phenotype
  • Co-delivery of anticancer small molecule, protein, and RNA therapeutics to TAMs

Representative Publication

Alexander MP, Fiering SN, Ostroff GR, Cramer RA, Mullins DW. Beta-glucan-induced trained innate immunity mediates antitumor efficacy in the mouse lung. J Immunol. 2016;196(1 supp):1731–1742.

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