Search Close Search
Page Menu

Emma Watson, PhD

Research Focus - Cancer Chromosome Genetics

  • Modeling
    • Cancer genomes by utilizing forward-and reverse-genetic technologies to generate tumor-like genomes from normal, healthy human cells.

      Large-scale chromosomal abnormalities that occur at very high frequencies in tumors, like +1q which occurs in >60% of breast cancers.

      Breast, renal, colon, pancreas, and desmoid tumor genomes in the relevant cell types of origin for these cancer types, using the hundreds of cell line resources we generated.

  • Discovering
    • How cancer chromosomal abnormalities drive pro-growth phenotypes during tumor genome evolution.

Representative Publication

Patel RS, Romero R, Watson EV, et al. A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells. Nat Commun. 2022;13(1):256.

Read Publication

More Publications