Search Close Search
Page Menu

Daniel N. Bolon, PhD

Research Focus - Investigating Drug Resistance in Oncogenes Using Protein Fitness Landscapes

  • Develop mutational scanning approaches to systematically identify and quantify all drug-resistance mutations in a protein
  • Elucidate protein fitness landscapes to successfully predict clinical resistance and guide treatment choices
  • Determine drug resistance potential, which can be incorporated into preclinical development studies

Representative Publication

Ma L, Boucher JI, Paulsen J, et al. CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy. Proc Natl Acad Sci USA. 2017;114(44):11751-11756.

Read Publication

More Publications