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Located in Worcester, Massachusetts, the UMass Cancer Center is committed to providing exceptional patient care, conducting cutting-edge research at the highest level, offering excellence in education and training, and serving as an educational resource and advocate for the Central Massachusetts community.
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Expert Cancer Care in Central Massachusetts

We offer comprehensive cancer care for all childhood and adult cancers, combining state-of-the-art treatments with compassionate support for patients and their families.
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Cutting-Edge Cancer Research

We carry out front-line research in basic, translational, clinical and population-based discovery to find newer, better methods for the prevention, detection, diagnosis, and treatment of cancer.
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The UMass Cancer Center is dedicated to training the next generation of cancer researchers, clinicians and physician-scientists.
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Cole Haynes, PhD

Professor, Department of Molecular, Cell and Cancer Biology, UMass Chan Medical School

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Cole Haynes, PhD

Research Focus - Mitochondrial UPR Regulation of Metabolism, Physiology and Pathology

Studying mitochondria-to-nuclear communication
Elucidating the mechanism by which the mitochondrial network is established following cell division
Investigating mitochondrial maintenance during aging
Determining the mechanism and impact of mutant mtDNA propagation in cancer
Developing therapeutic approaches to mitochondrial diseases

Representative Publication

Shpilka T, Haynes CM. The mitochondrial UPR: mechanisms, physiologic functions and implications in ageing. Nat Rev Mol Cell Biol. 2018;19(2):109-120.

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Research News

Cole Haynes receives prestigious NIH MERIT award for research on mitochondria repair

Cole M. Haynes, PhD, professor of molecular, cell & cancer biology, has received a Method to Extend Research in Time award from the National Institute on Aging for his research on repair and regeneration of mitochondria dysfunction, a mechanism associated with age-related diseases such as Parkinson’s and Alzheimer’s.

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Research News

Cole Haynes receives investigator award from HHMI, Gates & Simons foundations

Cole Haynes, PhD, was named one of 84 faculty scholars by the Howard Hughes Medical Institute (HHMI), the Simons Foundation, and the Bill & Melinda Gates Foundation.

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