Brian Kelch, PhD

Research Focus - Structural Studies of DNA Replication and Repair Proteins Involved in Cancer

• Study of sliding clamp proteins—factors involved in DNA replication and repair—mutations in which cause the rare disease PARD (PCNA-Associated DNA Repair Disorder), which results in skin cancer
• Determination that the molecular basis for PARD is due to the inability of the sliding clamp to function with critical DNA repair proteins
• Investigation of proteins that load sliding clamps onto DNA, revealing the basis by which mutations in the loader may lead to various forms of cancer

Representative Publication

Gaubitz C, Liu X, Magrino J, et al. Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanism. bioRxiv, 2020

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