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Barbara Osborne, PhD

Research Focus - Signaling Pathways and T Cell Activation

  • The role of Notch signaling in T cell activation
  • Gamma secretase modulation of T cell activation
  • Mechanisms of checkpoint inhibition of T cells
  • 3D Spheroid models of cancer for studies of immune checkpoint blockade in various tumor models
  • Delivery of checkpoint inhibitors using rAAV

Representative Publication

Hossain F, Majumder S, Ucar DA, et al. Notch signaling in myeloid cells as a regulator of tumor immune responses. Front Immunol. 2018;9:1288.

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