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Athma Pai, PhD

Research Focus - The Efficiency of mRNA Splicing Regulation in Cancer

  • Exploring the kinetics of mRNA splicing regulation.
  • Investigating the tradeoff between temporal specificity and splice site fidelity in mis-regulated gene expression programs.
  • Understanding the functional consequences of recurrent cancer-associated mutations in core splicing regulatory factors.
  • Developing novel genomic approaches for measuring the temporal coordination between disparate steps of mRNA processing.

Representative Publication

Pai AA, Luca F. Environmental influences on RNA processing: Biochemical, molecular and genetic regulators of cellular response. Wiley Interdiscip Rev RNA. 2019 Jan;10(1):e1503.

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