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Biochemistry and Molecular Biotechnology
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New Bolon Lab 2024
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Research
Research Area 1
Research Area 2
Research Area 3
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New Bolon Lab 2024
Home
Research
Research Area 1
Research Area 2
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Our most recent publications:
Total:
displaying 10 out of
55
results
Dominant negative mutations in yeast Hsp90 indicate triage decision mechanism targeting client proteins for degradation
Wednesday, November 20, 2024
Author(s):
Julia M Flynn,Margot E Joyce,Daniel N A Bolon
Source:
Molecular biology of the cell
Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance
Tuesday, March 12, 2024
Author(s):
Julia M Flynn,Sarah N Zvornicanin,Tenzin Tsepal,Ala M Shaqra,Nese Kurt Yilmaz,Weiping Jia,Stephanie Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon
Source:
ACS infectious diseases
Dominant negative mutations in yeast Hsp90 reveal triage decision mechanism targeting client proteins for degradation
Tuesday, January 23, 2024
Author(s):
Julia M Flynn,Margot E Joyce,Daniel N A Bolon
Source:
bioRxiv : the preprint server for biology
Systematic profiling of dominant ubiquitin variants reveals key functional nodes contributing to evolutionary selection
Friday, September 01, 2023
Author(s):
Amrita Arpita Padhy,David Mavor,Subhashree Sahoo,Daniel N A Bolon,Parul Mishra
Source:
Cell reports
Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease
Friday, June 30, 2023
Author(s):
Julia M Flynn,Qiu Yu J Huang,Sarah N Zvornicanin,Gila Schneider-Nachum,Ala M Shaqra,Nese Kurt Yilmaz,Stephanie A Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon
Source:
ACS infectious diseases
A complete allosteric map of a GTPase switch in its native cellular network
Tuesday, February 21, 2023
Author(s):
Christopher J P Mathy,Parul Mishra,Julia M Flynn,Tina Perica,David Mavor,Daniel N A Bolon,Tanja Kortemme
Source:
Cell systems
Mutational fitness landscape and drug resistance
Monday, January 09, 2023
Author(s):
Julia Flynn,Neha Samant,Gily Schneider-Nachum,Tsepal Tenzin,Daniel N A Bolon
Source:
Current opinion in structural biology
Sequence dependencies and biophysical features both govern cleavage of diverse cut-sites by HIV protease
Tuesday, June 28, 2022
Author(s):
Neha Samant,Gily Nachum,Tenzin Tsepal,Daniel N A Bolon
Source:
Protein science : a publication of the Protein Society
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance
Tuesday, June 21, 2022
Author(s):
Ala M Shaqra,Sarah N Zvornicanin,Qiu Yu J Huang,Gordon J Lockbaum,Mark Knapp,Laura Tandeske,David T Bakan,Julia Flynn,Daniel N A Bolon,Stephanie Moquin,Dustin Dovala,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Nature communications
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
Monday, June 20, 2022
Author(s):
Julia M Flynn,Neha Samant,Gily Schneider-Nachum,David T Barkan,Nese Kurt Yilmaz,Celia A Schiffer,Stephanie A Moquin,Dustin Dovala,Daniel N A Bolon
Source:
eLife
Analyses of HIV proteases variants at the threshold of viability reveals relationships between processing efficiency and fitness
Friday, March 18, 2022
Author(s):
Gily Schneider-Nachum,Julia Flynn,David Mavor,Celia A Schiffer,Daniel N A Bolon
Source:
Virus evolution
Quantitative structural analysis of influenza virus by cryo-electron tomography and convolutional neural networks
Tuesday, March 15, 2022
Author(s):
Qiuyu J Huang,Kangkang Song,Chen Xu,Daniel N A Bolon,Jennifer P Wang,Robert W Finberg,Celia A Schiffer,Mohan Somasundaran
Source:
Structure (London, England : 1993)
Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y
Wednesday, January 19, 2022
Author(s):
Li Jiang,Neha Samant,Ping Liu,Mohan Somasundaran,Jeffrey D Jensen,Wayne A Marasco,Timothy F Kowalik,Celia A Schiffer,Robert W Finberg,Jennifer P Wang,Daniel N A Bolon
Source:
Journal of virology
Comprehensive fitness maps of Hsp90 show widespread environmental dependence
Thursday, March 05, 2020
Author(s):
Julia M Flynn,Ammeret Rossouw,Pamela Cote-Hammarlof,Inês Fragata,David Mavor,Carl Hollins,Claudia Bank,Daniel Na Bolon
Source:
eLife
Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance
Wednesday, July 31, 2019
Author(s):
Mina Henes,Gordon J Lockbaum,Klajdi Kosovrasti,Florian Leidner,Gily S Nachum,Ellen A Nalivaika,Sook-Kyung Lee,Ean Spielvogel,Shuntai Zhou,Ronald Swanstrom,Daniel N A Bolon,Nese Kurt Yilmaz,Celia A Schiffer
Source:
ACS chemical biology
Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature
Wednesday, February 13, 2019
Author(s):
Jeffrey I Boucher,Daniel N A Bolon,Dan S Tawfik
Source:
Protein science : a publication of the Protein Society
Constrained Mutational Sampling of Amino Acids in HIV-1 Protease Evolution
Wednesday, February 06, 2019
Author(s):
Jeffrey I Boucher,Troy W Whitfield,Ann Dauphin,Gily Nachum,Carl Hollins,Konstantin B Zeldovich,Ronald Swanstrom,Celia A Schiffer,Jeremy Luban,Daniel N A Bolon
Source:
Molecular biology and evolution
Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody
Friday, November 02, 2018
Author(s):
Kristina L Prachanronarong,Aneth S Canale,Ping Liu,Mohan Somasundaran,Shurong Hou,Yu-Ping Poh,Thomas Han,Quan Zhu,Nicholas Renzette,Konstantin B Zeldovich,Timothy F Kowalik,Nese Kurt-Yilmaz,Jeffrey D Jensen,Daniel N A Bolon,Wayne A Marasco,Robert W Finberg,Celia A Schiffer,Jennifer P Wang
Source:
Journal of virology
Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance
Wednesday, July 25, 2018
Author(s):
David Mavor,Kyle A Barlow,Daniel Asarnow,Yuliya Birman,Derek Britain,Weilin Chen,Evan M Green,Lillian R Kenner,Bruk Mensa,Leanna S Morinishi,Charlotte A Nelson,Erin M Poss,Pooja Suresh,Ruilin Tian,Taylor Arhar,Beatrice E Ary,David P Bauer,Ian D Bergman,Rachel M Brunetti,Cynthia M Chio,Shizhong A Dai,Miles S Dickinson,Susanna K Elledge,Cole V M Helsell,Nathan L Hendel,Emily Kang,Nadja Kern,Matvei S Khoroshkin,Lisa L Kirkemo,Greyson R Lewis,Kevin Lou,Wesley M Marin,Alison M Maxwell,Peter F McTigue,Douglas Myers-Turnbull,Tamas L Nagy,Andrew M Natale,Keely Oltion,Sergei Pourmal,Gabriel K Reder,Nicholas J Rettko,Peter J Rohweder,Daniel M C Schwarz,Sophia K Tan,Paul V Thomas,Ryan W Tibble,Jason P Town,Mary K Tsai,Fatima S Ugur,Douglas R Wassarman,Alexander M Wolff,Taia S Wu,Derek Bogdanoff,Jennifer Li,Kurt S Thorn,Shane O'Conchúir,Danielle L Swaney,Eric D Chow,Hiten D Madhani,Sy Redding,Daniel N Bolon,Tanja Kortemme,Joseph L DeRisi,Martin Kampmann,James S Fraser
Source:
Biology open
Pervasive contingency and entrenchment in a billion years of Hsp90 evolution
Sunday, April 08, 2018
Author(s):
Tyler N Starr,Julia M Flynn,Parul Mishra,Daniel N A Bolon,Joseph W Thornton
Source:
Proceedings of the National Academy of Sciences of the United States of America
Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness
Thursday, February 22, 2018
Author(s):
Aneth S Canale,Sergey V Venev,Troy W Whitfield,Daniel R Caffrey,Wayne A Marasco,Celia A Schiffer,Timothy F Kowalik,Jeffrey D Jensen,Robert W Finberg,Konstantin B Zeldovich,Jennifer P Wang,Daniel N A Bolon
Source:
Journal of molecular biology
Evolutionary mechanisms studied through protein fitness landscapes
Sunday, January 21, 2018
Author(s):
Aneth S Canale,Pamela A Cote-Hammarlof,Julia M Flynn,Daniel Na Bolon
Source:
Current opinion in structural biology
CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy
Sunday, October 29, 2017
Author(s):
Leyuan Ma,Jeffrey I Boucher,Janet Paulsen,Sebastian Matuszewski,Christopher A Eide,Jianhong Ou,Garrett Eickelberg,Richard D Press,Lihua Julie Zhu,Brian J Druker,Susan Branford,Scot A Wolfe,Jeffrey D Jensen,Celia A Schiffer,Michael R Green,Daniel N Bolon
Source:
Proceedings of the National Academy of Sciences of the United States of America
A synthetic biology approach to probing nucleosome symmetry
Wednesday, September 13, 2017
Author(s):
Yuichi Ichikawa,Caitlin F Connelly,Alon Appleboim,Thomas Cr Miller,Hadas Jacobi,Nebiyu A Abshiru,Hsin-Jung Chou,Yuanyuan Chen,Upasna Sharma,Yupeng Zheng,Paul M Thomas,Hsuiyi V Chen,Vineeta Bajaj,Christoph W Müller,Neil L Kelleher,Nir Friedman,Daniel Na Bolon,Oliver J Rando,Paul D Kaufman
Source:
eLife
The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution
Friday, September 01, 2017
Author(s):
Louise Ormond,Ping Liu,Sebastian Matuszewski,Nicholas Renzette,Claudia Bank,Konstantin Zeldovich,Daniel N Bolon,Timothy F Kowalik,Robert W Finberg,Jeffrey D Jensen,Jennifer P Wang
Source:
Genome biology and evolution
The diverse roles of Hsp90 and where to find them
Friday, January 06, 2017
Author(s):
Patricija Van Oosten-Hawle,Daniel N A Bolon,Paul LaPointe
Source:
Nature structural & molecular biology
Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations
Tuesday, November 08, 2016
Author(s):
Maria Duenas-Decamp,Li Jiang,Daniel Bolon,Paul R Clapham
Source:
PLoS pathogens
An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy
Sunday, August 28, 2016
Author(s):
Claudia Bank,Nicholas Renzette,Ping Liu,Sebastian Matuszewski,Hyunjin Shim,Matthieu Foll,Daniel N A Bolon,Konstantin B Zeldovich,Timothy F Kowalik,Robert W Finberg,Jennifer P Wang,Jeffrey D Jensen
Source:
Evolution; international journal of organic evolution
Editorial
Tuesday, May 24, 2016
Author(s):
Daniel N A Bolon,David Baker,Dan S Tawfik
Source:
Protein science : a publication of the Protein Society
Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting
Tuesday, April 26, 2016
Author(s):
David Mavor,Kyle Barlow,Samuel Thompson,Benjamin A Barad,Alain R Bonny,Clinton L Cario,Garrett Gaskins,Zairan Liu,Laura Deming,Seth D Axen,Elena Caceres,Weilin Chen,Adolfo Cuesta,Rachel E Gate,Evan M Green,Kaitlin R Hulce,Weiyue Ji,Lillian R Kenner,Bruk Mensa,Leanna S Morinishi,Steven M Moss,Marco Mravic,Ryan K Muir,Stefan Niekamp,Chimno I Nnadi,Eugene Palovcak,Erin M Poss,Tyler D Ross,Eugenia C Salcedo,Stephanie K See,Meena Subramaniam,Allison W Wong,Jennifer Li,Kurt S Thorn,Shane Ó Conchúir,Benjamin P Roscoe,Eric D Chow,Joseph L DeRisi,Tanja Kortemme,Daniel N Bolon,James S Fraser
Source:
eLife
Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function
Wednesday, April 13, 2016
Author(s):
Parul Mishra,Julia M Flynn,Tyler N Starr,Daniel N A Bolon
Source:
Cell reports
Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature
Friday, March 25, 2016
Author(s):
Jeffrey I Boucher,Daniel N A Bolon,Dan S Tawfik
Source:
Protein science : a publication of the Protein Society
A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance
Tuesday, December 15, 2015
Author(s):
Li Jiang,Ping Liu,Claudia Bank,Nicholas Renzette,Kristina Prachanronarong,Lutfu S Yilmaz,Daniel R Caffrey,Konstantin B Zeldovich,Celia A Schiffer,Timothy F Kowalik,Jeffrey D Jensen,Robert W Finberg,Jennifer P Wang,Daniel N A Bolon
Source:
Journal of molecular biology
Mechanistic Asymmetry in Hsp90 Dimers
Tuesday, April 07, 2015
Author(s):
Julia M Flynn,Parul Mishra,Daniel N A Bolon
Source:
Journal of molecular biology
Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment
Thursday, February 26, 2015
Author(s):
Konstantin B Zeldovich,Ping Liu,Nicholas Renzette,Matthieu Foll,Serena T Pham,Sergey V Venev,Glen R Gallagher,Daniel N Bolon,Evelyn A Kurt-Jones,Jeffrey D Jensen,Daniel R Caffrey,Celia A Schiffer,Timothy F Kowalik,Jennifer P Wang,Robert W Finberg
Source:
Molecular biology and evolution
A systematic survey of an intragenic epistatic landscape
Thursday, November 06, 2014
Author(s):
Claudia Bank,Ryan T Hietpas,Jeffrey D Jensen,Daniel N A Bolon
Source:
Molecular biology and evolution
Viewing protein fitness landscapes through a next-gen lens
Thursday, October 16, 2014
Author(s):
Jeffrey I Boucher,Pamela Cote,Julia Flynn,Li Jiang,Aneth Laban,Parul Mishra,Benjamin P Roscoe,Daniel N A Bolon
Source:
Genetics
Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast
Wednesday, May 28, 2014
Author(s):
Benjamin P Roscoe,Daniel N A Bolon
Source:
Journal of molecular biology
Influenza virus drug resistance: a time-sampled population genetics perspective
Tuesday, March 04, 2014
Author(s):
Matthieu Foll,Yu-Ping Poh,Nicholas Renzette,Anna Ferrer-Admetlla,Claudia Bank,Hyunjin Shim,Anna-Sapfo Malaspinas,Gregory Ewing,Ping Liu,Daniel Wegmann,Daniel R Caffrey,Konstantin B Zeldovich,Daniel N Bolon,Jennifer P Wang,Timothy F Kowalik,Celia A Schiffer,Robert W Finberg,Jeffrey D Jensen
Source:
PLoS genetics
Designed Hsp90 heterodimers reveal an asymmetric ATPase-driven mechanism in vivo
Tuesday, January 28, 2014
Author(s):
Parul Mishra,Daniel N A Bolon
Source:
Molecular cell
Alanine scan of core positions in ubiquitin reveals links between dynamics, stability, and function
Tuesday, December 24, 2013
Author(s):
Shirley Y Lee,Lester Pullen,Daniel J Virgil,Carlos A Castañeda,Dulith Abeykoon,Daniel N A Bolon,David Fushman
Source:
Journal of molecular biology
Shifting fitness landscapes in response to altered environments
Thursday, December 05, 2013
Author(s):
Ryan T Hietpas,Claudia Bank,Jeffrey D Jensen,Daniel N A Bolon
Source:
Evolution; international journal of organic evolution
Latent effects of Hsp90 mutants revealed at reduced expression levels
Friday, July 05, 2013
Author(s):
Li Jiang,Parul Mishra,Ryan T Hietpas,Konstantin B Zeldovich,Daniel N A Bolon
Source:
PLoS genetics
Analyses of the effects of all ubiquitin point mutants on yeast growth rate
Tuesday, February 05, 2013
Author(s):
Benjamin P Roscoe,Kelly M Thayer,Konstantin B Zeldovich,David Fushman,Daniel N A Bolon
Source:
Journal of molecular biology
Fitness analyses of all possible point mutations for regions of genes in yeast
Saturday, June 23, 2012
Author(s):
Ryan Hietpas,Benjamin Roscoe,Li Jiang,Daniel N A Bolon
Source:
Nature protocols
Solubility-promoting function of Hsp90 contributes to client maturation and robust cell growth
Tuesday, June 05, 2012
Author(s):
Natalie W Pursell,Parul Mishra,Daniel N A Bolon
Source:
Eukaryotic cell
Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease
Friday, February 03, 2012
Author(s):
Seema Mittal,Yufeng Cai,Madhavi N L Nalam,Daniel N A Bolon,Celia A Schiffer
Source:
Journal of the American Chemical Society
Bound for observation
Saturday, November 19, 2011
Author(s):
Daniel N A Bolon
Source:
Journal of molecular biology
Hsp90 and client protein maturation
Thursday, September 08, 2011
Author(s):
Natalie Wayne,Parul Mishra,Daniel N Bolon
Source:
Methods in molecular biology (Clifton, N.J.)
Experimental illumination of a fitness landscape
Wednesday, April 06, 2011
Author(s):
Ryan T Hietpas,Jeffrey D Jensen,Daniel N A Bolon
Source:
Proceedings of the National Academy of Sciences of the United States of America
Enforced N-domain proximity stimulates Hsp90 ATPase activity and is compatible with function in vivo
Tuesday, February 01, 2011
Author(s):
Lester Pullen,Daniel N Bolon
Source:
The Journal of biological chemistry
Charge-rich regions modulate the anti-aggregation activity of Hsp90
Saturday, July 10, 2010
Author(s):
Natalie Wayne,Daniel N Bolon
Source:
Journal of molecular biology
Modular control of cross-oligomerization: analysis of superstabilized Hsp90 homodimers in vivo
Friday, November 13, 2009
Author(s):
Natalie Wayne,Yushuan Lai,Les Pullen,Daniel N Bolon
Source:
The Journal of biological chemistry
Watching proteins in motion
Friday, October 30, 2009
Author(s):
Mary Munson,Daniel N Bolon
Source:
Genome biology
Dimerization of Hsp90 is required for in vivo function. Design and analysis of monomers and dimers
Wednesday, October 03, 2007
Author(s):
Natalie Wayne,Daniel N Bolon
Source:
The Journal of biological chemistry
In the News
Latest INSERT LAB NAME HERE news as reported by the UMass Chan Communications Office
Communicating science: Daniel Bolon explains drug resistance in cancer cells
October 04, 2021
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