Skip to main content
Skip to search
Skip to main menu
Skip to page specific menu
Skip to footer area
Site Menu
Close
Search the New Bolon Lab 2024 site
Search
A-Z
|
Search All UMass Chan Sites
Research
Research
in vivo Mechanism of Hsp90
Analyses of DN Mutations
Mpro Drug Resistance
Publications
The Lab
The Lab
The PI
Lab Members
Lab Culture
Lab News
Contact
Additional Resources
About
Admissions
Education
Faculty
Research
Diversity
Giving
Search
Close Search
Bolon Lab
Biochemistry and Molecular Biotechnology
Page Menu
x
New Bolon Lab 2024
Home
Research
in vivo Mechanism of Hsp90
Analyses of DN Mutations
Mpro Drug Resistance
Publications
The Lab
The PI
Lab Members
Lab Culture
Lab News
Contact
New Bolon Lab 2024
Home
Research
in vivo Mechanism of Hsp90
Analyses of DN Mutations
Mpro Drug Resistance
Publications
The Lab
The PI
Lab Members
Lab Culture
Lab News
Contact
Our most recent publications:
Total:
displaying 10 out of
57
results
Mutational scan of self-cleavage by HIV-1 protease provides new views of a conformationally dynamic mechanism
Monday, November 24, 2025
Author(s):
Gily S Nachum,Jeffrey I Boucher,Julia M Flynn,Princess Quansah,Sivan Nachum,Daniel N A Bolon
Source:
bioRxiv : the preprint server for biology
Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50
Friday, April 04, 2025
Author(s):
Sarah N Zvornicanin,Ala M Shaqra,Julia Flynn,Heidi Carias Martinez,Weiping Jia,Stephanie Moquin,Dustin Dovala,Daniel N Bolon,Nese Kurt Yilmaz,Celia A Schiffer
Source:
mBio
Dominant negative mutations in yeast Hsp90 indicate triage decision mechanism targeting client proteins for degradation
Wednesday, November 20, 2024
Author(s):
Julia M Flynn,Margot E Joyce,Daniel N A Bolon
Source:
Molecular biology of the cell
Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance
Tuesday, March 12, 2024
Author(s):
Julia M Flynn,Sarah N Zvornicanin,Tenzin Tsepal,Ala M Shaqra,Nese Kurt Yilmaz,Weiping Jia,Stephanie Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon
Source:
ACS infectious diseases
Dominant negative mutations in yeast Hsp90 reveal triage decision mechanism targeting client proteins for degradation
Tuesday, January 23, 2024
Author(s):
Julia M Flynn,Margot E Joyce,Daniel N A Bolon
Source:
bioRxiv : the preprint server for biology
Systematic profiling of dominant ubiquitin variants reveals key functional nodes contributing to evolutionary selection
Friday, September 01, 2023
Author(s):
Amrita Arpita Padhy,David Mavor,Subhashree Sahoo,Daniel N A Bolon,Parul Mishra
Source:
Cell reports
Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease
Friday, June 30, 2023
Author(s):
Julia M Flynn,Qiu Yu J Huang,Sarah N Zvornicanin,Gila Schneider-Nachum,Ala M Shaqra,Nese Kurt Yilmaz,Stephanie A Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon
Source:
ACS infectious diseases
A complete allosteric map of a GTPase switch in its native cellular network
Tuesday, February 21, 2023
Author(s):
Christopher J P Mathy,Parul Mishra,Julia M Flynn,Tina Perica,David Mavor,Daniel N A Bolon,Tanja Kortemme
Source:
Cell systems
Mutational fitness landscape and drug resistance
Monday, January 09, 2023
Author(s):
Julia Flynn,Neha Samant,Gily Schneider-Nachum,Tsepal Tenzin,Daniel N A Bolon
Source:
Current opinion in structural biology
Sequence dependencies and biophysical features both govern cleavage of diverse cut-sites by HIV protease
Tuesday, June 28, 2022
Author(s):
Neha Samant,Gily Nachum,Tenzin Tsepal,Daniel N A Bolon
Source:
Protein science : a publication of the Protein Society
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance
Tuesday, June 21, 2022
Author(s):
Ala M Shaqra,Sarah N Zvornicanin,Qiu Yu J Huang,Gordon J Lockbaum,Mark Knapp,Laura Tandeske,David T Bakan,Julia Flynn,Daniel N A Bolon,Stephanie Moquin,Dustin Dovala,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Nature communications
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
Monday, June 20, 2022
Author(s):
Julia M Flynn,Neha Samant,Gily Schneider-Nachum,David T Barkan,Nese Kurt Yilmaz,Celia A Schiffer,Stephanie A Moquin,Dustin Dovala,Daniel N A Bolon
Source:
eLife
Analyses of HIV proteases variants at the threshold of viability reveals relationships between processing efficiency and fitness
Friday, March 18, 2022
Author(s):
Gily Schneider-Nachum,Julia Flynn,David Mavor,Celia A Schiffer,Daniel N A Bolon
Source:
Virus evolution
Quantitative structural analysis of influenza virus by cryo-electron tomography and convolutional neural networks
Tuesday, March 15, 2022
Author(s):
Qiuyu J Huang,Kangkang Song,Chen Xu,Daniel N A Bolon,Jennifer P Wang,Robert W Finberg,Celia A Schiffer,Mohan Somasundaran
Source:
Structure (London, England : 1993)
Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y
Wednesday, January 19, 2022
Author(s):
Li Jiang,Neha Samant,Ping Liu,Mohan Somasundaran,Jeffrey D Jensen,Wayne A Marasco,Timothy F Kowalik,Celia A Schiffer,Robert W Finberg,Jennifer P Wang,Daniel N A Bolon
Source:
Journal of virology
Comprehensive fitness maps of Hsp90 show widespread environmental dependence
Thursday, March 05, 2020
Author(s):
Julia M Flynn,Ammeret Rossouw,Pamela Cote-Hammarlof,Inês Fragata,David Mavor,Carl Hollins,Claudia Bank,Daniel Na Bolon
Source:
eLife
Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance
Wednesday, July 31, 2019
Author(s):
Mina Henes,Gordon J Lockbaum,Klajdi Kosovrasti,Florian Leidner,Gily S Nachum,Ellen A Nalivaika,Sook-Kyung Lee,Ean Spielvogel,Shuntai Zhou,Ronald Swanstrom,Daniel N A Bolon,Nese Kurt Yilmaz,Celia A Schiffer
Source:
ACS chemical biology
Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature
Wednesday, February 13, 2019
Author(s):
Jeffrey I Boucher,Daniel N A Bolon,Dan S Tawfik
Source:
Protein science : a publication of the Protein Society
Constrained Mutational Sampling of Amino Acids in HIV-1 Protease Evolution
Wednesday, February 06, 2019
Author(s):
Jeffrey I Boucher,Troy W Whitfield,Ann Dauphin,Gily Nachum,Carl Hollins,Konstantin B Zeldovich,Ronald Swanstrom,Celia A Schiffer,Jeremy Luban,Daniel N A Bolon
Source:
Molecular biology and evolution
Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody
Friday, November 02, 2018
Author(s):
Kristina L Prachanronarong,Aneth S Canale,Ping Liu,Mohan Somasundaran,Shurong Hou,Yu-Ping Poh,Thomas Han,Quan Zhu,Nicholas Renzette,Konstantin B Zeldovich,Timothy F Kowalik,Nese Kurt-Yilmaz,Jeffrey D Jensen,Daniel N A Bolon,Wayne A Marasco,Robert W Finberg,Celia A Schiffer,Jennifer P Wang
Source:
Journal of virology
Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance
Wednesday, July 25, 2018
Author(s):
David Mavor,Kyle A Barlow,Daniel Asarnow,Yuliya Birman,Derek Britain,Weilin Chen,Evan M Green,Lillian R Kenner,Bruk Mensa,Leanna S Morinishi,Charlotte A Nelson,Erin M Poss,Pooja Suresh,Ruilin Tian,Taylor Arhar,Beatrice E Ary,David P Bauer,Ian D Bergman,Rachel M Brunetti,Cynthia M Chio,Shizhong A Dai,Miles S Dickinson,Susanna K Elledge,Cole V M Helsell,Nathan L Hendel,Emily Kang,Nadja Kern,Matvei S Khoroshkin,Lisa L Kirkemo,Greyson R Lewis,Kevin Lou,Wesley M Marin,Alison M Maxwell,Peter F McTigue,Douglas Myers-Turnbull,Tamas L Nagy,Andrew M Natale,Keely Oltion,Sergei Pourmal,Gabriel K Reder,Nicholas J Rettko,Peter J Rohweder,Daniel M C Schwarz,Sophia K Tan,Paul V Thomas,Ryan W Tibble,Jason P Town,Mary K Tsai,Fatima S Ugur,Douglas R Wassarman,Alexander M Wolff,Taia S Wu,Derek Bogdanoff,Jennifer Li,Kurt S Thorn,Shane O'Conchúir,Danielle L Swaney,Eric D Chow,Hiten D Madhani,Sy Redding,Daniel N Bolon,Tanja Kortemme,Joseph L DeRisi,Martin Kampmann,James S Fraser
Source:
Biology open
Pervasive contingency and entrenchment in a billion years of Hsp90 evolution
Sunday, April 08, 2018
Author(s):
Tyler N Starr,Julia M Flynn,Parul Mishra,Daniel N A Bolon,Joseph W Thornton
Source:
Proceedings of the National Academy of Sciences of the United States of America
Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness
Thursday, February 22, 2018
Author(s):
Aneth S Canale,Sergey V Venev,Troy W Whitfield,Daniel R Caffrey,Wayne A Marasco,Celia A Schiffer,Timothy F Kowalik,Jeffrey D Jensen,Robert W Finberg,Konstantin B Zeldovich,Jennifer P Wang,Daniel N A Bolon
Source:
Journal of molecular biology
Evolutionary mechanisms studied through protein fitness landscapes
Sunday, January 21, 2018
Author(s):
Aneth S Canale,Pamela A Cote-Hammarlof,Julia M Flynn,Daniel Na Bolon
Source:
Current opinion in structural biology
CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy
Sunday, October 29, 2017
Author(s):
Leyuan Ma,Jeffrey I Boucher,Janet Paulsen,Sebastian Matuszewski,Christopher A Eide,Jianhong Ou,Garrett Eickelberg,Richard D Press,Lihua Julie Zhu,Brian J Druker,Susan Branford,Scot A Wolfe,Jeffrey D Jensen,Celia A Schiffer,Michael R Green,Daniel N Bolon
Source:
Proceedings of the National Academy of Sciences of the United States of America
A synthetic biology approach to probing nucleosome symmetry
Wednesday, September 13, 2017
Author(s):
Yuichi Ichikawa,Caitlin F Connelly,Alon Appleboim,Thomas Cr Miller,Hadas Jacobi,Nebiyu A Abshiru,Hsin-Jung Chou,Yuanyuan Chen,Upasna Sharma,Yupeng Zheng,Paul M Thomas,Hsuiyi V Chen,Vineeta Bajaj,Christoph W Müller,Neil L Kelleher,Nir Friedman,Daniel Na Bolon,Oliver J Rando,Paul D Kaufman
Source:
eLife
The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution
Friday, September 01, 2017
Author(s):
Louise Ormond,Ping Liu,Sebastian Matuszewski,Nicholas Renzette,Claudia Bank,Konstantin Zeldovich,Daniel N Bolon,Timothy F Kowalik,Robert W Finberg,Jeffrey D Jensen,Jennifer P Wang
Source:
Genome biology and evolution
The diverse roles of Hsp90 and where to find them
Friday, January 06, 2017
Author(s):
Patricija Van Oosten-Hawle,Daniel N A Bolon,Paul LaPointe
Source:
Nature structural & molecular biology
Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations
Tuesday, November 08, 2016
Author(s):
Maria Duenas-Decamp,Li Jiang,Daniel Bolon,Paul R Clapham
Source:
PLoS pathogens
An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy
Sunday, August 28, 2016
Author(s):
Claudia Bank,Nicholas Renzette,Ping Liu,Sebastian Matuszewski,Hyunjin Shim,Matthieu Foll,Daniel N A Bolon,Konstantin B Zeldovich,Timothy F Kowalik,Robert W Finberg,Jennifer P Wang,Jeffrey D Jensen
Source:
Evolution; international journal of organic evolution
Editorial
Tuesday, May 24, 2016
Author(s):
Daniel N A Bolon,David Baker,Dan S Tawfik
Source:
Protein science : a publication of the Protein Society
Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting
Tuesday, April 26, 2016
Author(s):
David Mavor,Kyle Barlow,Samuel Thompson,Benjamin A Barad,Alain R Bonny,Clinton L Cario,Garrett Gaskins,Zairan Liu,Laura Deming,Seth D Axen,Elena Caceres,Weilin Chen,Adolfo Cuesta,Rachel E Gate,Evan M Green,Kaitlin R Hulce,Weiyue Ji,Lillian R Kenner,Bruk Mensa,Leanna S Morinishi,Steven M Moss,Marco Mravic,Ryan K Muir,Stefan Niekamp,Chimno I Nnadi,Eugene Palovcak,Erin M Poss,Tyler D Ross,Eugenia C Salcedo,Stephanie K See,Meena Subramaniam,Allison W Wong,Jennifer Li,Kurt S Thorn,Shane Ó Conchúir,Benjamin P Roscoe,Eric D Chow,Joseph L DeRisi,Tanja Kortemme,Daniel N Bolon,James S Fraser
Source:
eLife
Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function
Wednesday, April 13, 2016
Author(s):
Parul Mishra,Julia M Flynn,Tyler N Starr,Daniel N A Bolon
Source:
Cell reports
Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature
Friday, March 25, 2016
Author(s):
Jeffrey I Boucher,Daniel N A Bolon,Dan S Tawfik
Source:
Protein science : a publication of the Protein Society
A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance
Tuesday, December 15, 2015
Author(s):
Li Jiang,Ping Liu,Claudia Bank,Nicholas Renzette,Kristina Prachanronarong,Lutfu S Yilmaz,Daniel R Caffrey,Konstantin B Zeldovich,Celia A Schiffer,Timothy F Kowalik,Jeffrey D Jensen,Robert W Finberg,Jennifer P Wang,Daniel N A Bolon
Source:
Journal of molecular biology
Mechanistic Asymmetry in Hsp90 Dimers
Tuesday, April 07, 2015
Author(s):
Julia M Flynn,Parul Mishra,Daniel N A Bolon
Source:
Journal of molecular biology
Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment
Thursday, February 26, 2015
Author(s):
Konstantin B Zeldovich,Ping Liu,Nicholas Renzette,Matthieu Foll,Serena T Pham,Sergey V Venev,Glen R Gallagher,Daniel N Bolon,Evelyn A Kurt-Jones,Jeffrey D Jensen,Daniel R Caffrey,Celia A Schiffer,Timothy F Kowalik,Jennifer P Wang,Robert W Finberg
Source:
Molecular biology and evolution
A systematic survey of an intragenic epistatic landscape
Thursday, November 06, 2014
Author(s):
Claudia Bank,Ryan T Hietpas,Jeffrey D Jensen,Daniel N A Bolon
Source:
Molecular biology and evolution
Viewing protein fitness landscapes through a next-gen lens
Thursday, October 16, 2014
Author(s):
Jeffrey I Boucher,Pamela Cote,Julia Flynn,Li Jiang,Aneth Laban,Parul Mishra,Benjamin P Roscoe,Daniel N A Bolon
Source:
Genetics
Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast
Wednesday, May 28, 2014
Author(s):
Benjamin P Roscoe,Daniel N A Bolon
Source:
Journal of molecular biology
Influenza virus drug resistance: a time-sampled population genetics perspective
Tuesday, March 04, 2014
Author(s):
Matthieu Foll,Yu-Ping Poh,Nicholas Renzette,Anna Ferrer-Admetlla,Claudia Bank,Hyunjin Shim,Anna-Sapfo Malaspinas,Gregory Ewing,Ping Liu,Daniel Wegmann,Daniel R Caffrey,Konstantin B Zeldovich,Daniel N Bolon,Jennifer P Wang,Timothy F Kowalik,Celia A Schiffer,Robert W Finberg,Jeffrey D Jensen
Source:
PLoS genetics
Designed Hsp90 heterodimers reveal an asymmetric ATPase-driven mechanism in vivo
Tuesday, January 28, 2014
Author(s):
Parul Mishra,Daniel N A Bolon
Source:
Molecular cell
Alanine scan of core positions in ubiquitin reveals links between dynamics, stability, and function
Tuesday, December 24, 2013
Author(s):
Shirley Y Lee,Lester Pullen,Daniel J Virgil,Carlos A Castañeda,Dulith Abeykoon,Daniel N A Bolon,David Fushman
Source:
Journal of molecular biology
Shifting fitness landscapes in response to altered environments
Thursday, December 05, 2013
Author(s):
Ryan T Hietpas,Claudia Bank,Jeffrey D Jensen,Daniel N A Bolon
Source:
Evolution; international journal of organic evolution
Latent effects of Hsp90 mutants revealed at reduced expression levels
Friday, July 05, 2013
Author(s):
Li Jiang,Parul Mishra,Ryan T Hietpas,Konstantin B Zeldovich,Daniel N A Bolon
Source:
PLoS genetics
Analyses of the effects of all ubiquitin point mutants on yeast growth rate
Tuesday, February 05, 2013
Author(s):
Benjamin P Roscoe,Kelly M Thayer,Konstantin B Zeldovich,David Fushman,Daniel N A Bolon
Source:
Journal of molecular biology
Fitness analyses of all possible point mutations for regions of genes in yeast
Saturday, June 23, 2012
Author(s):
Ryan Hietpas,Benjamin Roscoe,Li Jiang,Daniel N A Bolon
Source:
Nature protocols
Solubility-promoting function of Hsp90 contributes to client maturation and robust cell growth
Tuesday, June 05, 2012
Author(s):
Natalie W Pursell,Parul Mishra,Daniel N A Bolon
Source:
Eukaryotic cell
Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease
Friday, February 03, 2012
Author(s):
Seema Mittal,Yufeng Cai,Madhavi N L Nalam,Daniel N A Bolon,Celia A Schiffer
Source:
Journal of the American Chemical Society
Bound for observation
Saturday, November 19, 2011
Author(s):
Daniel N A Bolon
Source:
Journal of molecular biology
Hsp90 and client protein maturation
Thursday, September 08, 2011
Author(s):
Natalie Wayne,Parul Mishra,Daniel N Bolon
Source:
Methods in molecular biology (Clifton, N.J.)
Experimental illumination of a fitness landscape
Wednesday, April 06, 2011
Author(s):
Ryan T Hietpas,Jeffrey D Jensen,Daniel N A Bolon
Source:
Proceedings of the National Academy of Sciences of the United States of America
Enforced N-domain proximity stimulates Hsp90 ATPase activity and is compatible with function in vivo
Tuesday, February 01, 2011
Author(s):
Lester Pullen,Daniel N Bolon
Source:
The Journal of biological chemistry
Charge-rich regions modulate the anti-aggregation activity of Hsp90
Saturday, July 10, 2010
Author(s):
Natalie Wayne,Daniel N Bolon
Source:
Journal of molecular biology
Modular control of cross-oligomerization: analysis of superstabilized Hsp90 homodimers in vivo
Friday, November 13, 2009
Author(s):
Natalie Wayne,Yushuan Lai,Les Pullen,Daniel N Bolon
Source:
The Journal of biological chemistry
Watching proteins in motion
Friday, October 30, 2009
Author(s):
Mary Munson,Daniel N Bolon
Source:
Genome biology
Dimerization of Hsp90 is required for in vivo function. Design and analysis of monomers and dimers
Wednesday, October 03, 2007
Author(s):
Natalie Wayne,Daniel N Bolon
Source:
The Journal of biological chemistry
In the News
Latest Bolon Lab news as reported by the UMass Chan Communications Office
Communicating science: Daniel Bolon explains drug resistance in cancer cells
October 04, 2021
Back To Top ▲
