Instrumentation

Thermo Scientific Orbitrap Astral Zoom with Vanquish Neo UHPLC

~quantitative proteomics~

The Thermo Scientific Orbitrap Astral Zoom represents the next generation of proteomics, combining the exceptional mass accuracy and resolving power of Orbitrap technology with the ultra-fast acquisition speed of the Astral analyzer. This advanced hybrid platform delivers unprecedented depth, sensitivity, and throughput, enabling the identification and quantification of thousands of proteins in minutes with outstanding reproducibility and data quality. Advanced data-independent acquisition (DIA) workflows provide comprehensive, unbiased, and highly reproducible protein quantification across large sample cohorts, making the system ideal for quantitative proteomics, biomarker discovery, translational research, and systems biology. The Orbitrap Astral Zoom also excels in single-cell, spatial, and low-input proteomics, offering deep proteome coverage from limited sample amounts. With enhanced ion transmission, ultra-fast scan rates, and high mass accuracy, it enables confident detection of low-abundance proteins and post-translational modifications, empowering researchers to accelerate discovery and generate transformative biological insights.

Learn more: Thermo Scientific Orbitrap Astral Zoom

Bruker timsTOF Pro 2 with nanoElute UPLC

~quantitative proteomics~

Unlock the power of next-generation proteomics with the Bruker timsTOF Pro 2, a cutting-edge timed ion mobility quadrupole time-of-flight (QTOF) mass spectrometer delivering exceptional sensitivity, speed, and depth. Designed for high-throughput single-shot workflows or deep proteome coverage, it supports flexible nanoflow gradients to meet diverse research needs. Perfect for stable isotope labeling (SILAC) or label-free quantitation, the timsTOF Pro 2 ensures accurate, reproducible results for complex studies. Its integrated PaSER (Parallel Search Engine in Real Time) provides instant qualitative feedback on sample integrity and system performance, enabling confident decisions during acquisition. With DIA-PASEF (Data-Independent Acquisition combined with Parallel Accumulation Serial Fragmentation), this platform delivers comprehensive, unbiased proteome coverage and exceptional reproducibility ideal for large-scale studies and biomarker discovery.

Learn more: Bruker timsTOF Pro 2

Thermo Scientific Orbitrap Fusion Lumos Tribrid with Waters NanoAcquity UPLC

~quantitative proteomics~

The Thermo Scientific Orbitrap Fusion Lumos Tribrid remains a reliable and versatile platform for a broad range of proteomics applications. Combining quadrupole, Orbitrap, and linear ion trap technologies with HCD, CID, and ETD fragmentation capabilities, the system provides robust protein identification, post-translational modification characterization, and targeted protein analyses. Integration of FAIMS Pro™ technology enhances analyte selectivity and improves performance for complex biological samples. While next-generation platforms such as the Orbitrap Astral Zoom and timsTOF Pro 2 now provide substantially greater speed, sensitivity, and proteome depth for large-scale discovery studies, the Fusion Lumos remains well-suited for routine proteomics workflows, targeted analyses, TMT-based experiments, PTM characterization, and method development. Its proven reliability and flexibility make it an excellent platform for foundational proteomics studies and specialized applications that benefit from its diverse fragmentation options.

Thermo Scientific Q Exactive HF-X with Vanquish Flex UHPLC

 ~small molecule profiling and targeted quantitation~

The Thermo Scientific Q Exactive HF-X is a high-performance quadrupole-Orbitrap mass spectrometer that combines high-resolution accurate-mass (HRAM) detection with HCD fragmentation and UHPLC separation. The platform supports a broad range of applications, including untargeted small-molecule profiling, compound characterization, biomarker discovery, and targeted quantitation. Delivering excellent mass accuracy, sensitivity, and quantitative reproducibility, the Q Exactive HF-X provides reliable identification and measurement of small molecules across diverse biological samples. Its robust performance and proven reliability make it an ideal platform for routine small-molecule analysis, method development, and translational research applications.

Waters Synapt G2-Si with Acquity UPLC

A quadrupole time-of-flight mass spectrometer enabled with gas-phase ion mobility separations for improved analyte selectivity.

~intact protein, mAb, and oligonucleotide analysis~

• intact and reduced proteins, mAb's, and oligonucleotides analyzed by ESI LC-MS with a Waters Acquity UPLC. UPLC fitted with an inline UV detector.
• nanoflow UPLC options also available.

~mass spectrometry tissue imaging~

• in-situ tissue imaging for mapping the spatial distribution of exogenous drugs or endogenous lipids and metabolites in sectioned tissue.
• Nd:YAG high repetition laser for matrix-assisted laserdesorption/ionization (MALDI) applications.
• HTX Technologies TM-Sprayer for matrix application.
• desorption electrospray ionization (DESI) option available.