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Individuals  >85 years of age comprise more than 15% of all stroke patients. Atrial fibrillation becomes increasingly common in the very elderly, and this may contribute to their increased incidence of stroke. Amyloid angiopathy (and the lobar hemorrhages that are associated with this small vessel pathology) is also most common in the elderly. However, accumulation and destabilization of atherosclerotic plaques with accompanying thrombus formation remains the pathology underlying the majority of strokes, regardless of age.