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Kara Smith, MD, publication report from PubMed

Total: 20 results

  • Patient Communication: Semantics as a Barrier to Humanism in Critical Care

    Thursday, July 18, 2024
    Author(s): Laura Istanboulian,Kelly M Smith,Karen Soldatić
    Source: Journal of nursing care quality
    No abstract

  • Aging modulates the effect of dietary glycemic index on gut microbiota composition in mice

    Wednesday, July 17, 2024
    Author(s): Ying Zhu,Emily N Yeo,Kelsey M Smith,Andrew S Greenberg,Sheldon Rowan
    Source: The Journal of nutrition
    CONCLUSIONS: These findings illustrate the complex interplay between diet and aging in shaping the gut microbiota, potentially contributing to age-related disease.

  • Granulosa cell metabolism at ovulation correlates with oocyte competence and is disrupted by obesity and aging

    Tuesday, July 16, 2024
    Author(s): Atsushi Morimoto,Ryan D Rose,Kirsten M Smith,Doan T Dinh,Takashi Umehara,Yasmyn E Winstanley,Hiroaki Shibahara,Darryl L Russell,Rebecca L Robker
    Source: Human reproduction (Oxford, England)
    STUDY QUESTION: Is oocyte developmental competence associated with changes in granulosa cell (GC) metabolism?

  • Hepatic artery infusion pump (HAIP) therapy in combination with targeted delivery of IL-12 for patients with metastatic colorectal cancer or intrahepatic cholangiocarcinoma: a phase II trial protocol

    Thursday, July 11, 2024
    Author(s): Jack H Victory,Emily C Smith,Carrie E Ryan,Jacob Lambdin,Amber Leila Sarvestani,Lindsay R Friedman,Alyssa V Eade,Carolina Larrain,Tracey Pu,Kenneth Luberice,Bhavishya Ramamoorthy,Ashley J Rainey,Cathleen E Hannah,Kathleen M Smith,Donna Mabry,Changqing Xie,Jeremy L Davis,Andrew M Blakely,James L Gulley,Jeffrey Schlom,Cecilia Monge,Tim F Greten,Jonathan M Hernandez
    Source: Journal of gastrointestinal oncology
    BACKGROUND: Treatment of advanced liver tumors remains challenging. Although immune checkpoint inhibition has revolutionized treatment for many cancers, responses in colorectal liver metastases and biliary tract cancers remain suboptimal. Investigation into additional immunomodulatory therapies for these cancers is needed. Interleukin-12 (IL-12) is a pro-inflammatory cytokine with robust anti-tumor activity, but systemic adverse effects largely terminated therapeutic development of recombinant...

  • Multi-ancestry Genome-Wide Association Meta-Analysis Identifies Novel Loci in Atopic Dermatitis

    Monday, July 01, 2024
    Author(s): Meritxell Oliva,Mrinal K Sarkar,Michael E March,Amir Hossein Saeidian,Frank D Mentch,Chen-Lin Hsieh,Fanying Tang,Ranjitha Uppala,Matthew T Patrick,Qinmengge Li,Rachael Bogle,J Michelle Kahlenberg,Deborah Watson,Joseph T Glessner,Lam C Tsoi,Hakon Hakonarson,Johann E Gudjonsson,Kathleen M Smith,Bridget Riley-Gillis
    Source: medRxiv : the preprint server for health sciences
    Atopic dermatitis (AD) is a highly heritable and common inflammatory skin condition affecting children and adults worldwide. Multi-ancestry approaches to AD genetic association studies are poised to boost power to detect genetic signal and identify ancestry-specific loci contributing to AD risk. Here, we present a multi-ancestry GWAS meta-analysis of twelve AD cohorts from five ancestral populations totaling 56,146 cases and 602,280 controls. We report 101 genomic loci associated with AD,...

  • Seizure-Related Falls and Near Falls in LGI1-IgG Autoimmune Encephalitis

    Friday, June 28, 2024
    Author(s): Xiaoyang Li,Pranjal Gupta,Kelsey M Smith,Ajay Madhavan,Mohamed Rezk,Anastasia Zekeridou,Eoin P Flanagan,Andrew McKeon,Sean J Pittock,Jeffrey W Britton,Divyanshu Dubey
    Source: Neurology. Clinical practice
    OBJECTIVES: To study the frequency, causes, and consequences of seizure-related falls and near falls in LGI1-IgG autoimmune encephalitis.

  • What Will People Think? How College Students Evaluate Bystander Intervention Behavior

    Monday, June 24, 2024
    Author(s): Jody Clay-Warner,Justine Tinkler,Sarah M Groh,Kylie M Smith,Sharyn Potter
    Source: Journal of interpersonal violence
    Many colleges utilize bystander intervention programs to address gender-based violence. The goal of these programs is to help students overcome barriers to intervention, including evaluation inhibition, which occurs when bystanders expect to be viewed negatively for intervening. We have limited information, though, on how college students evaluate bystanders who intervene. Specifically, we do not know whether evaluations of bystanders who engage in different levels of intervention vary across...

  • Commentary: Engagement for Research and Quality Improvement - More Than Just Words

    Monday, June 17, 2024
    Author(s): Kerry Kuluski,Katie Dainty,Kelly M Smith
    Source: Healthcare quarterly (Toronto, Ont.)
    We reflect on the paper from Hahn-Goldberg et al. (2024) who shared key learnings from a pan-Canadian quality improvement (QI) and patient engagement care transition initiative called Bridge-to-Home. In considering the approach and outcomes presented in their paper, we have generated reflections and practical suggestions on how to amplify engagement work even further: (1) patient engagement and QI are about relationships; (2) seamlessly implementing complex interventions across siloed...

  • Risk of Seizure Recurrence Due to Autoimmune Encephalitis With NMDAR, LGI1, CASPR2, and GABABR Antibodies: Implications for Return to Driving

    Wednesday, June 05, 2024
    Author(s): Anna Rada,Anne Hagemann,Charlotte Aaberg Poulsen,Tobias Baumgartner,Timea Berki,Morten Blaabjerg,Juliette Brenner,Jeffrey W Britton,Andrew Christiana,Nicolás L Ciano-Petersen,Yvette Crijnen,Martin Elišák,Antonio Farina,Alec R Friedman,Zsófia Hayden,Julien Hébert,Martin Holtkamp,Zhen Hong,Jerome Honnorat,Maria Ilyas-Feldmann,Sarosh R Irani,Stjepana Kovac,Petr Marusic,Sergio Muñiz-Castrillo,Sudarshini Ramanathan,Kelsey M Smith,Claude Steriade,Christine Strippel,Rainer Surges,Maarten J Titulaer,Christopher E Uy,Juna M de Vries,Christian G Bien,Ulrich Specht
    Source: Neurology(R) neuroimmunology & neuroinflammation
    BACKGROUND AND OBJECTIVES: Patients with ongoing seizures are usually not allowed to drive. The prognosis for seizure freedom is favorable in patients with autoimmune encephalitis (AIE) with antibodies against NMDA receptor (NMDAR), leucine-rich glioma-inactivated 1 (LGI1), contactin-associated protein-like 2 (CASPR2), and the gamma-aminobutyric-acid B receptor (GABA(B)R). We hypothesized that after a seizure-free period of 3 months, patients with AIE have a seizure recurrence risk of

  • Autoimmune-associated seizure disorders

    Friday, May 31, 2024
    Author(s): Kelsey M Smith,Adrian Budhram,Christian Geis,Andrew McKeon,Claude Steriade,Coral M Stredny,Maarten J Titulaer,Jeffrey W Britton
    Source: Epileptic disorders : international epilepsy journal with videotape
    With the discovery of an expanding number of neural autoantibodies, autoimmune etiologies of seizures have been increasingly recognized. Clinical phenotypes have been identified in association with specific underlying antibodies, allowing an earlier diagnosis. These phenotypes include faciobrachial dystonic seizures with LGI1 encephalitis, neuropsychiatric presentations associated with movement disorders and seizures in NMDA-receptor encephalitis, and chronic temporal lobe epilepsy in GAD65...

  • Synthesis and Regioselective Functionalization of Tetrafluorobenzo-[α]-Fused BOPYPY Dyes

    Wednesday, May 08, 2024
    Author(s): Sebastian O Oloo,Guanyu Zhang,Petia Bobadova-Parvanova,Seleen Al Horani,Masa Al Horani,Frank R Fronczek,Kevin M Smith,Maria da Graça H Vicente
    Source: Inorganic chemistry
    The synthesis of a new bis-BF(2) tetrafluorobenzo-[α]-fused BOPYPY dye from 4,5,6,7-tetrafluoroisoindole and 2-hydrazinopyrazine is reported. The regioselectivity of nucleophilic substitution reactions at the periphery of the tetrafluorinated BOPYPY and its α-bromo derivative were investigated using N-, O-, S-, and C-based nucleophiles. Among the aromatic fluorine atoms, the F² atom is consistently regioselectively substituted, except when the α-position contains a thiophenol group; in this...

  • Pregnant smokers can be encouraged to switch to vaping

    Wednesday, April 24, 2024
    Author(s): Francesca Pesola,Katie Myers Smith,Anna Phillips-Waller,Dunja Przulj,Robert Walton,Hayden McRobbie,Tim Coleman,Sarah Lewis,Miranda Clark,Michael Ussher,Felix Naughton,Peter Hajek
    Source: Addiction (Abingdon, England)
    No abstract

  • HEIDI: an experiment-management platform enabling high-throughput fragment and compound screening

    Friday, April 12, 2024
    Author(s): A Metz,D P Stegmann,E H Panepucci,S Buehlmann,C Y Huang,K E McAuley,M Wang,J A Wojdyla,M E Sharpe,K M L Smith
    Source: Acta crystallographica. Section D, Structural biology
    The Swiss Light Source facilitates fragment-based drug-discovery campaigns for academic and industrial users through the Fast Fragment and Compound Screening (FFCS) software suite. This framework is further enriched by the option to utilize the Smart Digital User (SDU) software for automated data collection across the PXI, PXII and PXIII beamlines. In this work, the newly developed HEIDI webpage (https://heidi.psi.ch) is introduced: a platform crafted using state-of-the-art software architecture...

  • A comprehensive hierarchical comparison of structural connectomes in Major Depressive Disorder cases v. controls in two large population samples

    Monday, March 18, 2024
    Author(s): Gladi Thng,Xueyi Shen,Aleks Stolicyn,Mark J Adams,Hon Wah Yeung,Venia Batziou,Eleanor L S Conole,Colin R Buchanan,Stephen M Lawrie,Mark E Bastin,Andrew M McIntosh,Ian J Deary,Elliot M Tucker-Drob,Simon R Cox,Keith M Smith,Liana Romaniuk,Heather C Whalley
    Source: Psychological medicine
    CONCLUSION: Our results suggest that the brain's fundamental rich club structure is similar in MDD cases and controls, but subtle topological differences exist across the brain. Consistent with recent large-scale neuroimaging findings, our findings offer a connectomic perspective on a similar scale and support the idea that minimal differences exist between MDD cases and controls.

  • FAST functional connectivity implicates P300 connectivity in working memory deficits in Alzheimer's disease

    Monday, March 11, 2024
    Author(s): Om Roy,Yashar Moshfeghi,Agustin Ibanez,Francisco Lopera,Mario A Parra,Keith M Smith
    Source: ArXiv
    Measuring transient functional connectivity is an important challenge in Electroencephalogram (EEG) research. Here, the rich potential for insightful, discriminative information of brain activity offered by high temporal resolution is confounded by the inherent noise of the medium and the spurious nature of correlations computed over short temporal windows. We propose a novel methodology to overcome these problems called Filter Average Short-Term (FAST) functional connectivity. First, long-term,...

  • 3D printed chamber for live cell imaging on an upright epifluorescence microscope

    Friday, March 01, 2024
    Author(s): Deborah J Rogers,Brennan P Bergeron,Glen M Watson,Karen Müller Smith
    Source: Journal of biological education
    Live cell imaging is a standard technique in experimental biology that enables the observation of isolated cells and tissue slices in real time; and the testing of cellular responses to changes in buffer composition. However, most live cell imaging devices require the use of dedicated microscopes and/or specialized stage adaptors, and come at a reasonably high cost. We employed 3D printing technology to create a low-cost imaging chamber with side ports to exchange fluids, to be used on upright...

  • The functional and anatomical characterization of three spinal output pathways of the anterolateral tract

    Thursday, February 29, 2024
    Author(s): Haichao Chen,Isabel H Bleimeister,Eileen K Nguyen,Jie Li,Abby Yilin Cui,Harrison J Stratton,Kelly M Smith,Mark L Baccei,Sarah E Ross
    Source: Cell reports
    The nature of spinal output pathways that convey nociceptive information to the brain has been the subject of controversy. Here, we provide anatomical, molecular, and functional characterizations of two distinct anterolateral pathways: one, ascending in the lateral spinal cord, triggers nociceptive behaviors, and the other one, ascending in the ventral spinal cord, when inhibited, leads to sensorimotor deficits. Moreover, the lateral pathway consists of at least two subtypes. The first is a...

  • Selective transcriptomic dysregulation of metabolic pathways in liver and retina by short- and long-term dietary hyperglycemia

    Friday, February 09, 2024
    Author(s): Anupam K Mondal,Daniel C Brock,Sheldon Rowan,Zhi-Hong Yang,Krishna Vamsi Rojulpote,Kelsey M Smith,Sarah G Francisco,Eloy Bejarano,Milton A English,Amy Deik,Sarah Jeanfavre,Clary B Clish,Alan T Remaley,Allen Taylor,Anand Swaroop
    Source: iScience
    A high glycemic index (HGI) diet induces hyperglycemia, a risk factor for diseases affecting multiple organ systems. Here, we evaluated tissue-specific adaptations in the liver and retina after feeding HGI diet to mice for 1 or 12 month. In the liver, genes associated with inflammation and fatty acid metabolism were altered within 1 month of HGI diet, whereas 12-month HGI diet-fed group showed dysregulated expression of cytochrome P450 genes and overexpression of lipogenic factors including...

  • Phenotypic Characterization and Draft Genome Sequence Analyses of Two Novel Endospore-Forming Sporosarcina spp. Isolated from Canada Goose (Branta canadensis) Feces

    Tuesday, January 23, 2024
    Author(s): Jitendra Keshri,Kristina M Smith,Molly K Svendsen,Haley R Keillor,Madeline L Moss,Haley J Jordan,Abigail M Larkin,Johnna K Garrish,John Eric Line,Patrick N Ball,Brian B Oakley,Bruce S Seal
    Source: Microorganisms
    In an attempt to isolate new probiotic bacteria, two Gram-variable, spore-forming, rod-shaped aerobic bacteria designated as strain A4 and A15 were isolated from the feces of Canada geese (Branta canadensis). Strain A4 was able to grow in high salt levels and exhibited lipase activity, while A15 did not propagate under these conditions. Both were positive for starch hydrolysis, and they inhibited the growth of Staphylococcus aureus. The strains of the 16S rRNA sequence shared only 94% similarity...

  • Three-month Delay in Rotator Cuff Repair: 2-year Follow-up

    Monday, January 22, 2024
    Author(s): Christopher Clinker,Karch M Smith,Hiroaki Ishikawa,Christopher Joyce,Robert Z Tashjian,Peter N Chalmers
    Source: Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
    INTRODUCTION: This study examined 2-year outcomes of patients who underwent delayed rotator cuff repair (RCR) compared with those who underwent RCR without delay.