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Kara Smith, MD, publication report from PubMed

Total: 20 results
  • HEIDI: an experiment-management platform enabling high-throughput fragment and compound screening

    Friday, April 12, 2024
    Author(s): A Metz,D P Stegmann,E H Panepucci,S Buehlmann,C Y Huang,K E McAuley,M Wang,J A Wojdyla,M E Sharpe,K M L Smith
    Source: Acta crystallographica. Section D, Structural biology
    The Swiss Light Source facilitates fragment-based drug-discovery campaigns for academic and industrial users through the Fast Fragment and Compound Screening (FFCS) software suite. This framework is further enriched by the option to utilize the Smart Digital User (SDU) software for automated data collection across the PXI, PXII and PXIII beamlines. In this work, the newly developed HEIDI webpage ( is introduced: a platform crafted using state-of-the-art software architecture...
  • A comprehensive hierarchical comparison of structural connectomes in Major Depressive Disorder cases v. controls in two large population samples

    Monday, March 18, 2024
    Author(s): Gladi Thng,Xueyi Shen,Aleks Stolicyn,Mark J Adams,Hon Wah Yeung,Venia Batziou,Eleanor L S Conole,Colin R Buchanan,Stephen M Lawrie,Mark E Bastin,Andrew M McIntosh,Ian J Deary,Elliot M Tucker-Drob,Simon R Cox,Keith M Smith,Liana Romaniuk,Heather C Whalley
    Source: Psychological medicine
    CONCLUSION: Our results suggest that the brain's fundamental rich club structure is similar in MDD cases and controls, but subtle topological differences exist across the brain. Consistent with recent large-scale neuroimaging findings, our findings offer a connectomic perspective on a similar scale and support the idea that minimal differences exist between MDD cases and controls.
  • FAST functional connectivity implicates P300 connectivity in working memory deficits in Alzheimer's disease

    Monday, March 11, 2024
    Author(s): Om Roy,Yashar Moshfeghi,Agustin Ibanez,Francisco Lopera,Mario A Parra,Keith M Smith
    Source: ArXiv
    Measuring transient functional connectivity is an important challenge in Electroencephalogram (EEG) research. Here, the rich potential for insightful, discriminative information of brain activity offered by high temporal resolution is confounded by the inherent noise of the medium and the spurious nature of correlations computed over short temporal windows. We propose a novel methodology to overcome these problems called Filter Average Short-Term (FAST) functional connectivity. First, long-term,...
  • 3D printed chamber for live cell imaging on an upright epifluorescence microscope

    Friday, March 01, 2024
    Author(s): Deborah J Rogers,Brennan P Bergeron,Glen M Watson,Karen Müller Smith
    Source: Journal of biological education
    Live cell imaging is a standard technique in experimental biology that enables the observation of isolated cells and tissue slices in real time; and the testing of cellular responses to changes in buffer composition. However, most live cell imaging devices require the use of dedicated microscopes and/or specialized stage adaptors, and come at a reasonably high cost. We employed 3D printing technology to create a low-cost imaging chamber with side ports to exchange fluids, to be used on upright...
  • The functional and anatomical characterization of three spinal output pathways of the anterolateral tract

    Thursday, February 29, 2024
    Author(s): Haichao Chen,Isabel H Bleimeister,Eileen K Nguyen,Jie Li,Abby Yilin Cui,Harrison J Stratton,Kelly M Smith,Mark L Baccei,Sarah E Ross
    Source: Cell reports
    The nature of spinal output pathways that convey nociceptive information to the brain has been the subject of controversy. Here, we provide anatomical, molecular, and functional characterizations of two distinct anterolateral pathways: one, ascending in the lateral spinal cord, triggers nociceptive behaviors, and the other one, ascending in the ventral spinal cord, when inhibited, leads to sensorimotor deficits. Moreover, the lateral pathway consists of at least two subtypes. The first is a...
  • Selective transcriptomic dysregulation of metabolic pathways in liver and retina by short- and long-term dietary hyperglycemia

    Friday, February 09, 2024
    Author(s): Anupam K Mondal,Daniel C Brock,Sheldon Rowan,Zhi-Hong Yang,Krishna Vamsi Rojulpote,Kelsey M Smith,Sarah G Francisco,Eloy Bejarano,Milton A English,Amy Deik,Sarah Jeanfavre,Clary B Clish,Alan T Remaley,Allen Taylor,Anand Swaroop
    Source: iScience
    A high glycemic index (HGI) diet induces hyperglycemia, a risk factor for diseases affecting multiple organ systems. Here, we evaluated tissue-specific adaptations in the liver and retina after feeding HGI diet to mice for 1 or 12 month. In the liver, genes associated with inflammation and fatty acid metabolism were altered within 1 month of HGI diet, whereas 12-month HGI diet-fed group showed dysregulated expression of cytochrome P450 genes and overexpression of lipogenic factors including...
  • Phenotypic Characterization and Draft Genome Sequence Analyses of Two Novel Endospore-Forming Sporosarcina spp. Isolated from Canada Goose (Branta canadensis) Feces

    Tuesday, January 23, 2024
    Author(s): Jitendra Keshri,Kristina M Smith,Molly K Svendsen,Haley R Keillor,Madeline L Moss,Haley J Jordan,Abigail M Larkin,Johnna K Garrish,John Eric Line,Patrick N Ball,Brian B Oakley,Bruce S Seal
    Source: Microorganisms
    In an attempt to isolate new probiotic bacteria, two Gram-variable, spore-forming, rod-shaped aerobic bacteria designated as strain A4 and A15 were isolated from the feces of Canada geese (Branta canadensis). Strain A4 was able to grow in high salt levels and exhibited lipase activity, while A15 did not propagate under these conditions. Both were positive for starch hydrolysis, and they inhibited the growth of Staphylococcus aureus. The strains of the 16S rRNA sequence shared only 94% similarity...
  • Three-month Delay in Rotator Cuff Repair: 2-year Follow-up

    Monday, January 22, 2024
    Author(s): Christopher Clinker,Karch M Smith,Hiroaki Ishikawa,Christopher Joyce,Robert Z Tashjian,Peter N Chalmers
    Source: Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
    INTRODUCTION: This study examined 2-year outcomes of patients who underwent delayed rotator cuff repair (RCR) compared with those who underwent RCR without delay.
  • Addressing Fear of Negative Consequences of Overdose Response: A Qualitative Study of the Perceptions of Service Industry Workers Who Encounter an Opioid Overdose in an Urban Commercial District in Atlanta, Georgia

    Friday, January 19, 2024
    Author(s): Sarah Febres-Cordero,Lisa M Thompson,Oliver S Chalfant,Athena D F Sherman,Abigail K Winiker,Ursula A Kelly,Kylie M Smith
    Source: Workplace health & safety
    CONCLUSIONS/IMPLICATIONS FOR OCCUPATIONAL HEALTH PRACTICE: Our findings provide valuable insights for tailoring OEND training for service industry workers to confront fears associated with opioid overdose response in their places of work to decrease mortality from the opioid epidemic. Harm reduction approaches need to be sensitive to the places in which overdose occurs and who the overdose responder is likely to be, which requires appropriately tailoring OEND training for service industry...
  • Initial Antihypertensive Prescribing in Relation to Blood Pressure Among Florida Medicaid and Medicare Recipients in the OneFlorida+ Research Consortium

    Wednesday, January 17, 2024
    Author(s): Kayla M Smith,Shailina Keshwani,Marta G Walsh,Almut G Winterstein,Matthew J Gurka,Anne Libby,William R Hogan,Carl J Pepine,Rhonda M Cooper-DeHoff,Steven M Smith
    Source: Hypertension (Dallas, Tex. : 1979)
    No abstract
  • Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomized controlled trial

    Wednesday, January 17, 2024
    Author(s): Francesca Pesola,Katie Myers Smith,Anna Phillips-Waller,Dunja Przulj,Christopher Griffiths,Robert Walton,Hayden McRobbie,Tim Coleman,Sarah Lewis,Rachel Whitemore,Miranda Clark,Michael Ussher,Lesley Sinclair,Emily Seager,Sue Cooper,Linda Bauld,Felix Naughton,Peter Sasieni,Isaac Manyonda,Peter Hajek
    Source: Addiction (Abingdon, England)
    CONCLUSIONS: Regular use of e-cigarettes or nicotine patches by pregnant smokers does not appear to be associated with any adverse outcomes.
  • Therapeutic TNF Inhibitors Exhibit Differential Levels of Efficacy in Accelerating Cutaneous Wound Healing

    Tuesday, January 16, 2024
    Author(s): Yonghao Cao,Bohdan P Harvey,Liang Jin,Susan Westmoreland,Jing Wang,Munish Puri,Yingli Yang,Holly M Robb,Sultan Tanriverdi,Chenqi Hu,Xue Wang,Xiaofeng Xin,Yingchun Liu,Michael P Macoritto,Kathleen M Smith,Yu Tian,Kevin White,Timothy R D J Radstake,Zehra Kaymakcalan
    Source: JID innovations : skin science from molecules to population health
    Adalimumab but neither etanercept nor certolizumab-pegol has been reported to induce a wound-healing profile in vitro by regulating macrophage differentiation and matrix metalloproteinase expression, which may underlie the differences in efficacy between various TNF-α inhibitors in impaired wound healing in patients with hidradenitis suppurativa, a chronic inflammatory skin disease. To examine and compare the efficacy of various TNF inhibitors in cutaneous wound healing in vivo, a human TNF...
  • The evolution of (intergroup) peace hinges on how we define groups and peace

    Monday, January 15, 2024
    Author(s): Anne C Pisor,Kristopher M Smith,Jeffrey P Deminchuk
    Source: The Behavioral and brain sciences
    Glowacki defines peace as harmonious relationships between groups maintained without the threat of violence, where groups can be anything from families to nation states. However, defining such contentious concepts like "peace" and "groups" is a difficult task, and we discuss the implications of Glowacki's definitions for understanding intergroup relationships and their evolutionary history.
  • Job satisfaction and practice characteristics of shoulder and elbow surgeons: a survey of American Shoulder and Elbow Surgeons society members

    Sunday, December 17, 2023
    Author(s): Karch M Smith,Peter N Chalmers,Grant E Garrigues,William N Levine,Scott P Steinmann,Christopher S Klifto
    Source: Journal of shoulder and elbow surgery
    CONCLUSIONS: The majority of ASES member shoulder and elbow surgeons are satisfied with their training, their case volume and complexity, and their specialty choice. Fewer surgeons are satisfied with their elbow training and overall elbow case volume remains low among shoulder and elbow surgeons. Shoulder and elbow surgeons earlier in their careers perform fewer surgical cases, are less satisfied with their job availability and location, and completed more job applications for their first job...
  • 5- and 10-oxocorroles from β-octaalkylcorroles

    Wednesday, November 29, 2023
    Author(s): Lorena Di Zazzo,Sara Nardis,Fabrizio Caroleo,Francesco Pizzoli,Frank R Fronczek,Kevin M Smith,Beatrice Berionni Berna,Roberto Paolesse
    Source: Chemical communications (Cambridge, England)
    The reaction of Zn ions with β-octaalkylcorroles leads to the air oxidation of the macrocycle, with the formation of a mixture of 5- and 10-oxocorroles. Spectroscopic characterization confirms the antiaromatic character of these macrocycles. A simple synthetic protocol opens the way for more detailed studies of oxocorrole chemistry.
  • Long-distance social relationships can both undercut and promote local natural resource management

    Sunday, November 12, 2023
    Author(s): Anne C Pisor,Monique Borgerhoff Mulder,Kristopher M Smith
    Source: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
    The management of large common-pool resources, like fisheries and forests, is more difficult when more people and more communities can access them-a particular problem given increased population sizes, higher mobility and globalized trade in the Anthropocene. Social relationships spanning communities, such as kin relationships, business or trade relationships and friendships, can make management even more challenging by facilitating and transmitting norms of overharvesting. However, these...
  • Identification of a convergent spinal neuron population that encodes itch

    Tuesday, October 24, 2023
    Author(s): Tayler D Sheahan,Charles A Warwick,Abby Y Cui,David A A Baranger,Vijay J Perry,Kelly M Smith,Allison P Manalo,Eileen K Nguyen,H Richard Koerber,Sarah E Ross
    Source: bioRxiv : the preprint server for biology
    Itch is a protective sensation that drives scratching. Although specific cell types have been proposed to underlie itch, the neural circuit basis for itch remains unclear. Here, we used two-photon Ca^(2+) imaging of the dorsal horn to visualize the neuronal populations that are activated by itch-inducing agents. We identify a convergent population of spinal neurons that is defined by the expression of GRPR. Moreover, we discover that itch is conveyed to the brain via GRPR-expressing spinal...
  • Drug-resistant temporal lobe epilepsy with temporal encephaloceles: How far to resect

    Sunday, October 22, 2023
    Author(s): Kelsey M Smith,Kiran M Kanth,Karl N Krecke,Eva C Alden,Jay S Patel,Robert J Witte,Jamie J Van Gompel,Elson So,Jeffrey W Britton,Gregory D Cascino,Lily C Wong-Kisiel
    Source: Epilepsy & behavior : E&B
    CONCLUSION: Expert re-review of imaging and multi-modal advanced imaging improved TE identification. There was no statistical difference in seizure-free outcomes based on surgical extent. Preservation of verbal memory supports limited resection in dominant temporal cases.
  • Xaluritamig, a STEAP1 × CD3 XmAb 2+1 Immune Therapy for Metastatic Castration-Resistant Prostate Cancer: Results from Dose Exploration in a First-in-Human Study

    Friday, October 20, 2023
    Author(s): William K Kelly,Daniel C Danila,Chia-Chi Lin,Jae-Lyun Lee,Nobuaki Matsubara,Patrick J Ward,Andrew J Armstrong,David Pook,Miso Kim,Tanya B Dorff,Stefanie Fischer,Yung-Chang Lin,Lisa G Horvath,Christopher Sumey,Zhao Yang,Gabor Jurida,Kristen M Smith,Jamie N Connarn,Hweixian L Penny,Julia Stieglmaier,Leonard J Appleman
    Source: Cancer discovery
    Xaluritamig (AMG 509) is a six-transmembrane epithelial antigen of the prostate 1 (STEAP1)-targeted T-cell engager designed to facilitate lysis of STEAP1-expressing cancer cells, such as those in advanced prostate cancer. This first-in-human study reports monotherapy dose exploration for patients with metastatic castration-resistant prostate cancer (mCRPC), primarily taxane pretreated. Ninety-seven patients received ≥1 intravenous dose ranging from 0.001 to 2.0 mg weekly or every 2 weeks. MTD...
  • Construct validity of the international standards to document remaining autonomic function after spinal cord injury (ISAFSCI) (1st edition)

    Monday, October 09, 2023
    Author(s): Dilnur Kurban,Ross A Davidson,Karen M Smith,Marie Carlson,Jay Joseph,Stacy Elliott,Vanessa K Noonan,Nader Fallah,Andrei V Krassioukov
    Source: Spinal cord
    CONCLUSION: The construct validity of ISAFSCI (2012 1st Edition) for the General Autonomic Function component was considered to be weak while it was much stronger for the Lower Urinary Tract, Bowel and Sexual Function component based on a priori hypotheses. These results can inform future psychometric studies of the ISAFSCI (2021 2nd Edition).